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Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study
Endoscopic submucosal dissection (ESD) is an effective method for removing early colorectal lesions. However, research on the safety and efficacy of ESD in patients with various underlying conditions remains limited. This study retrospectively examined ESD outcomes in colorectal neoplasm patients fr...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573342/ https://www.ncbi.nlm.nih.gov/pubmed/37834899 http://dx.doi.org/10.3390/jcm12196255 |
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author | Kim, Dong-Hyun Jung, Yong-Wook Jin, Byung-Chul Oh, Hyung-Hoon Song, Hyo-Yeop Kim, Seong-Jung Myung, Dae-Seong Kim, Sang-Wook Lee, Jun Seo, Geom-Seog Joo, Young-Eun Kim, Hyun-Soo |
author_facet | Kim, Dong-Hyun Jung, Yong-Wook Jin, Byung-Chul Oh, Hyung-Hoon Song, Hyo-Yeop Kim, Seong-Jung Myung, Dae-Seong Kim, Sang-Wook Lee, Jun Seo, Geom-Seog Joo, Young-Eun Kim, Hyun-Soo |
author_sort | Kim, Dong-Hyun |
collection | PubMed |
description | Endoscopic submucosal dissection (ESD) is an effective method for removing early colorectal lesions. However, research on the safety and efficacy of ESD in patients with various underlying conditions remains limited. This study retrospectively examined ESD outcomes in colorectal neoplasm patients from five tertiary medical centers. The Charlson Comorbidity Index (CCI) and age-adjusted CCI (ACCI) were analyzed, and the differences in complete resection and complication rates were analyzed. The CCI, ACCI, and complication rates tended to gradually increase proportionally, and the complication resection rate increased from CCI 2 to ACCI 4 as the starting point, followed by a decreasing trend. Of these, 140 patients (9.7%) had a CCI score of 3 or higher. The high CCI group was older (70.6% vs. 64.7%, p < 0.01) and had a higher proportion of men (70.7% vs. 58.7%, p < 0.01) than the low CCI group. The high CCI group had a higher incidence of cancer than the low CCI group (77.9% vs. 65.2%, p < 0.01). The en bloc resection rate (90.0% vs. 89.3%, p = 0.79) and complete resection rate (75.7% vs. 81.2%, p = 0.12) were not significantly different between the two groups. Colorectal ESD can be safely and effectively performed in patients with various underlying medical conditions. |
format | Online Article Text |
id | pubmed-10573342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105733422023-10-14 Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study Kim, Dong-Hyun Jung, Yong-Wook Jin, Byung-Chul Oh, Hyung-Hoon Song, Hyo-Yeop Kim, Seong-Jung Myung, Dae-Seong Kim, Sang-Wook Lee, Jun Seo, Geom-Seog Joo, Young-Eun Kim, Hyun-Soo J Clin Med Article Endoscopic submucosal dissection (ESD) is an effective method for removing early colorectal lesions. However, research on the safety and efficacy of ESD in patients with various underlying conditions remains limited. This study retrospectively examined ESD outcomes in colorectal neoplasm patients from five tertiary medical centers. The Charlson Comorbidity Index (CCI) and age-adjusted CCI (ACCI) were analyzed, and the differences in complete resection and complication rates were analyzed. The CCI, ACCI, and complication rates tended to gradually increase proportionally, and the complication resection rate increased from CCI 2 to ACCI 4 as the starting point, followed by a decreasing trend. Of these, 140 patients (9.7%) had a CCI score of 3 or higher. The high CCI group was older (70.6% vs. 64.7%, p < 0.01) and had a higher proportion of men (70.7% vs. 58.7%, p < 0.01) than the low CCI group. The high CCI group had a higher incidence of cancer than the low CCI group (77.9% vs. 65.2%, p < 0.01). The en bloc resection rate (90.0% vs. 89.3%, p = 0.79) and complete resection rate (75.7% vs. 81.2%, p = 0.12) were not significantly different between the two groups. Colorectal ESD can be safely and effectively performed in patients with various underlying medical conditions. MDPI 2023-09-28 /pmc/articles/PMC10573342/ /pubmed/37834899 http://dx.doi.org/10.3390/jcm12196255 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Dong-Hyun Jung, Yong-Wook Jin, Byung-Chul Oh, Hyung-Hoon Song, Hyo-Yeop Kim, Seong-Jung Myung, Dae-Seong Kim, Sang-Wook Lee, Jun Seo, Geom-Seog Joo, Young-Eun Kim, Hyun-Soo Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study |
title | Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study |
title_full | Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study |
title_fullStr | Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study |
title_full_unstemmed | Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study |
title_short | Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study |
title_sort | effectiveness and safety of endoscopic submucosal dissection for colorectal neoplasm in patients with high charlson comorbidity index score: a hasid multicenter study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573342/ https://www.ncbi.nlm.nih.gov/pubmed/37834899 http://dx.doi.org/10.3390/jcm12196255 |
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