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Dysautonomia in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized in its typical presentation by a combination of lower and upper motor neuron symptoms, with a progressive course and fatal outcome. Due to increased recognition of the non-motor symptoms, it is currently considered a m...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573406/ https://www.ncbi.nlm.nih.gov/pubmed/37834374 http://dx.doi.org/10.3390/ijms241914927 |
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author | Oprisan, Alexandra L. Popescu, Bogdan Ovidiu |
author_facet | Oprisan, Alexandra L. Popescu, Bogdan Ovidiu |
author_sort | Oprisan, Alexandra L. |
collection | PubMed |
description | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized in its typical presentation by a combination of lower and upper motor neuron symptoms, with a progressive course and fatal outcome. Due to increased recognition of the non-motor symptoms, it is currently considered a multisystem disorder with great heterogeneity, regarding genetical, clinical, and neuropathological features. Often underestimated, autonomic signs and symptoms have been described in patients with ALS, and various method analyses have been used to assess autonomic nervous system involvement. The aim of this paper is to offer a narrative literature review on autonomic disturbances in ALS, based on the scarce data available to date. |
format | Online Article Text |
id | pubmed-10573406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105734062023-10-14 Dysautonomia in Amyotrophic Lateral Sclerosis Oprisan, Alexandra L. Popescu, Bogdan Ovidiu Int J Mol Sci Review Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized in its typical presentation by a combination of lower and upper motor neuron symptoms, with a progressive course and fatal outcome. Due to increased recognition of the non-motor symptoms, it is currently considered a multisystem disorder with great heterogeneity, regarding genetical, clinical, and neuropathological features. Often underestimated, autonomic signs and symptoms have been described in patients with ALS, and various method analyses have been used to assess autonomic nervous system involvement. The aim of this paper is to offer a narrative literature review on autonomic disturbances in ALS, based on the scarce data available to date. MDPI 2023-10-05 /pmc/articles/PMC10573406/ /pubmed/37834374 http://dx.doi.org/10.3390/ijms241914927 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Oprisan, Alexandra L. Popescu, Bogdan Ovidiu Dysautonomia in Amyotrophic Lateral Sclerosis |
title | Dysautonomia in Amyotrophic Lateral Sclerosis |
title_full | Dysautonomia in Amyotrophic Lateral Sclerosis |
title_fullStr | Dysautonomia in Amyotrophic Lateral Sclerosis |
title_full_unstemmed | Dysautonomia in Amyotrophic Lateral Sclerosis |
title_short | Dysautonomia in Amyotrophic Lateral Sclerosis |
title_sort | dysautonomia in amyotrophic lateral sclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573406/ https://www.ncbi.nlm.nih.gov/pubmed/37834374 http://dx.doi.org/10.3390/ijms241914927 |
work_keys_str_mv | AT oprisanalexandral dysautonomiainamyotrophiclateralsclerosis AT popescubogdanovidiu dysautonomiainamyotrophiclateralsclerosis |