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Dysautonomia in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized in its typical presentation by a combination of lower and upper motor neuron symptoms, with a progressive course and fatal outcome. Due to increased recognition of the non-motor symptoms, it is currently considered a m...

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Detalles Bibliográficos
Autores principales: Oprisan, Alexandra L., Popescu, Bogdan Ovidiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573406/
https://www.ncbi.nlm.nih.gov/pubmed/37834374
http://dx.doi.org/10.3390/ijms241914927
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author Oprisan, Alexandra L.
Popescu, Bogdan Ovidiu
author_facet Oprisan, Alexandra L.
Popescu, Bogdan Ovidiu
author_sort Oprisan, Alexandra L.
collection PubMed
description Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized in its typical presentation by a combination of lower and upper motor neuron symptoms, with a progressive course and fatal outcome. Due to increased recognition of the non-motor symptoms, it is currently considered a multisystem disorder with great heterogeneity, regarding genetical, clinical, and neuropathological features. Often underestimated, autonomic signs and symptoms have been described in patients with ALS, and various method analyses have been used to assess autonomic nervous system involvement. The aim of this paper is to offer a narrative literature review on autonomic disturbances in ALS, based on the scarce data available to date.
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spelling pubmed-105734062023-10-14 Dysautonomia in Amyotrophic Lateral Sclerosis Oprisan, Alexandra L. Popescu, Bogdan Ovidiu Int J Mol Sci Review Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized in its typical presentation by a combination of lower and upper motor neuron symptoms, with a progressive course and fatal outcome. Due to increased recognition of the non-motor symptoms, it is currently considered a multisystem disorder with great heterogeneity, regarding genetical, clinical, and neuropathological features. Often underestimated, autonomic signs and symptoms have been described in patients with ALS, and various method analyses have been used to assess autonomic nervous system involvement. The aim of this paper is to offer a narrative literature review on autonomic disturbances in ALS, based on the scarce data available to date. MDPI 2023-10-05 /pmc/articles/PMC10573406/ /pubmed/37834374 http://dx.doi.org/10.3390/ijms241914927 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oprisan, Alexandra L.
Popescu, Bogdan Ovidiu
Dysautonomia in Amyotrophic Lateral Sclerosis
title Dysautonomia in Amyotrophic Lateral Sclerosis
title_full Dysautonomia in Amyotrophic Lateral Sclerosis
title_fullStr Dysautonomia in Amyotrophic Lateral Sclerosis
title_full_unstemmed Dysautonomia in Amyotrophic Lateral Sclerosis
title_short Dysautonomia in Amyotrophic Lateral Sclerosis
title_sort dysautonomia in amyotrophic lateral sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573406/
https://www.ncbi.nlm.nih.gov/pubmed/37834374
http://dx.doi.org/10.3390/ijms241914927
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