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Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients

Introduction: COVID-19 is a disease characterized by high in-hospital mortality, which seems to be dependent on many predisposing factors. Objectives: The aim of this study was to analyze the clinical symptoms, abnormalities in the results of laboratory tests, and coexisting chronic diseases that in...

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Autores principales: Paciorek, Marcin, Bieńkowski, Carlo, Kowalska, Justyna Dominika, Skrzat-Klapaczyńska, Agata, Bednarska, Agnieszka, Krogulec, Dominika, Cholewińska, Grażyna, Kowalski, Jacek, Podlasin, Regina, Ropelewska-Łącka, Katarzyna, Wasilewski, Piotr, Boros, Piotr W., Martusiewicz-Boros, Magdalena M., Pulik, Piotr, Pihowicz, Andrzej, Horban, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573469/
https://www.ncbi.nlm.nih.gov/pubmed/37834907
http://dx.doi.org/10.3390/jcm12196264
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author Paciorek, Marcin
Bieńkowski, Carlo
Kowalska, Justyna Dominika
Skrzat-Klapaczyńska, Agata
Bednarska, Agnieszka
Krogulec, Dominika
Cholewińska, Grażyna
Kowalski, Jacek
Podlasin, Regina
Ropelewska-Łącka, Katarzyna
Wasilewski, Piotr
Boros, Piotr W.
Martusiewicz-Boros, Magdalena M.
Pulik, Piotr
Pihowicz, Andrzej
Horban, Andrzej
author_facet Paciorek, Marcin
Bieńkowski, Carlo
Kowalska, Justyna Dominika
Skrzat-Klapaczyńska, Agata
Bednarska, Agnieszka
Krogulec, Dominika
Cholewińska, Grażyna
Kowalski, Jacek
Podlasin, Regina
Ropelewska-Łącka, Katarzyna
Wasilewski, Piotr
Boros, Piotr W.
Martusiewicz-Boros, Magdalena M.
Pulik, Piotr
Pihowicz, Andrzej
Horban, Andrzej
author_sort Paciorek, Marcin
collection PubMed
description Introduction: COVID-19 is a disease characterized by high in-hospital mortality, which seems to be dependent on many predisposing factors. Objectives: The aim of this study was to analyze the clinical symptoms, abnormalities in the results of laboratory tests, and coexisting chronic diseases that independently affected the risk of in-hospital mortality in patients with COVID-19. Patients and Methods: We analyzed the records of patients with COVID-19 who were hospitalized from 6 March 2020 to 30 November 2021. Results: Out of the entire group of 2138 patients who were analyzed, 12.82% died during hospitalization. In-hospital mortality was independently associated with older age (OR 1.53, 95% CI 1.20–1.97); lower arterial blood oxygen saturation (OR 0.95, 95% CI 0.92–0.99); the presence of a neoplasm (OR 4.45, 95% CI 2.01–9.62), a stomach ulcer (OR 3.35, 95% CI 0.94–11.31), and dementia (OR 3.40, 95% CI 1.36–8.26); a higher score on the SOFA scale (OR 1.73, 95% CI 1.52–1.99); higher lactate dehydrogenase (LDH) (OR 1.08, 95% CI 1.05–1.12); higher N-terminal pro-brain natriuretic peptide (NT pro BNP) (OR 1.06, 95% CI 1.01–1.11); and lower total bilirubin in blood concentration (OR 0.94, 95% CI 0.90–0.99). Conclusions: We found that low oxygen saturation, old age, and the coexistence of cancer, gastric ulcers, and dementia syndrome were variables that independently increased mortality during hospitalization due to COVID-19. Moreover, we found that decreased platelet count and bilirubin concentration and increased levels of LDH and NT-proBNP were laboratory test results that independently indicated a higher risk of mortality. We also confirmed the usefulness of the SOFA scale in predicting treatment results. The ability to identify mortality risk factors on admission to hospital will facilitate both adjusting the intensity of treatment and the monitoring of patients infected with SARS-CoV-2.
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spelling pubmed-105734692023-10-14 Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients Paciorek, Marcin Bieńkowski, Carlo Kowalska, Justyna Dominika Skrzat-Klapaczyńska, Agata Bednarska, Agnieszka Krogulec, Dominika Cholewińska, Grażyna Kowalski, Jacek Podlasin, Regina Ropelewska-Łącka, Katarzyna Wasilewski, Piotr Boros, Piotr W. Martusiewicz-Boros, Magdalena M. Pulik, Piotr Pihowicz, Andrzej Horban, Andrzej J Clin Med Article Introduction: COVID-19 is a disease characterized by high in-hospital mortality, which seems to be dependent on many predisposing factors. Objectives: The aim of this study was to analyze the clinical symptoms, abnormalities in the results of laboratory tests, and coexisting chronic diseases that independently affected the risk of in-hospital mortality in patients with COVID-19. Patients and Methods: We analyzed the records of patients with COVID-19 who were hospitalized from 6 March 2020 to 30 November 2021. Results: Out of the entire group of 2138 patients who were analyzed, 12.82% died during hospitalization. In-hospital mortality was independently associated with older age (OR 1.53, 95% CI 1.20–1.97); lower arterial blood oxygen saturation (OR 0.95, 95% CI 0.92–0.99); the presence of a neoplasm (OR 4.45, 95% CI 2.01–9.62), a stomach ulcer (OR 3.35, 95% CI 0.94–11.31), and dementia (OR 3.40, 95% CI 1.36–8.26); a higher score on the SOFA scale (OR 1.73, 95% CI 1.52–1.99); higher lactate dehydrogenase (LDH) (OR 1.08, 95% CI 1.05–1.12); higher N-terminal pro-brain natriuretic peptide (NT pro BNP) (OR 1.06, 95% CI 1.01–1.11); and lower total bilirubin in blood concentration (OR 0.94, 95% CI 0.90–0.99). Conclusions: We found that low oxygen saturation, old age, and the coexistence of cancer, gastric ulcers, and dementia syndrome were variables that independently increased mortality during hospitalization due to COVID-19. Moreover, we found that decreased platelet count and bilirubin concentration and increased levels of LDH and NT-proBNP were laboratory test results that independently indicated a higher risk of mortality. We also confirmed the usefulness of the SOFA scale in predicting treatment results. The ability to identify mortality risk factors on admission to hospital will facilitate both adjusting the intensity of treatment and the monitoring of patients infected with SARS-CoV-2. MDPI 2023-09-28 /pmc/articles/PMC10573469/ /pubmed/37834907 http://dx.doi.org/10.3390/jcm12196264 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paciorek, Marcin
Bieńkowski, Carlo
Kowalska, Justyna Dominika
Skrzat-Klapaczyńska, Agata
Bednarska, Agnieszka
Krogulec, Dominika
Cholewińska, Grażyna
Kowalski, Jacek
Podlasin, Regina
Ropelewska-Łącka, Katarzyna
Wasilewski, Piotr
Boros, Piotr W.
Martusiewicz-Boros, Magdalena M.
Pulik, Piotr
Pihowicz, Andrzej
Horban, Andrzej
Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients
title Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients
title_full Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients
title_fullStr Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients
title_full_unstemmed Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients
title_short Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients
title_sort hospital admission factors independently affecting the risk of mortality of covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573469/
https://www.ncbi.nlm.nih.gov/pubmed/37834907
http://dx.doi.org/10.3390/jcm12196264
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