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Predictors of Improvement in Concomitant Tricuspid Regurgitation Following Transcatheter Edge-to-Edge Mitral Valve Repair

Background: Improvement in concomitant tricuspid regurgitation (TR) after mitral valve transcatheter edge-to-edge repair (M-TEER) for mitral regurgitation (MR) occurs frequently; however factors determining the post-procedural course of TR are not well understood. We investigated the parameters asso...

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Autores principales: Gröger, Matthias, Hirsch, Kai, Felbel, Dominik, Paukovitsch, Michael, Schneider, Leonhard Moritz, Markovic, Sinisa, Rottbauer, Wolfgang, Keßler, Mirjam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573471/
https://www.ncbi.nlm.nih.gov/pubmed/37834835
http://dx.doi.org/10.3390/jcm12196191
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author Gröger, Matthias
Hirsch, Kai
Felbel, Dominik
Paukovitsch, Michael
Schneider, Leonhard Moritz
Markovic, Sinisa
Rottbauer, Wolfgang
Keßler, Mirjam
author_facet Gröger, Matthias
Hirsch, Kai
Felbel, Dominik
Paukovitsch, Michael
Schneider, Leonhard Moritz
Markovic, Sinisa
Rottbauer, Wolfgang
Keßler, Mirjam
author_sort Gröger, Matthias
collection PubMed
description Background: Improvement in concomitant tricuspid regurgitation (TR) after mitral valve transcatheter edge-to-edge repair (M-TEER) for mitral regurgitation (MR) occurs frequently; however factors determining the post-procedural course of TR are not well understood. We investigated the parameters associated with TR improvement after M-TEER. Methods and Results: A total of 300 patients were consecutively included in this retrospective analysis. MR and TR severity as well as heart chamber metrics were assessed before the procedure and at follow-up. Device success was achieved in 97.3% of patients. TR decreased in 30.2% of patients. Patients with improved TR were more often female, had more severe TR at baseline, and their right heart dimensions at baseline trended to be smaller. Female sex (odds ratio (OR) 2.997), baseline MR-Grade (OR 3.181) and baseline TR-Grade (OR 2.653) independently predicted TR reduction. More pronounced right heart reverse remodeling was observed in patients with improved TR. TR regression independently predicted lower mortality (hazard ratio (HR) 0.333, 95% confidence interval 0.112–0.996, p = 0.049). Conclusions: A reduction in concomitant TR severity after M-TEER occurred mainly in females and in patients with high-grade TR and MR at baseline. TR regression is associated with better survival after M-TEER.
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spelling pubmed-105734712023-10-14 Predictors of Improvement in Concomitant Tricuspid Regurgitation Following Transcatheter Edge-to-Edge Mitral Valve Repair Gröger, Matthias Hirsch, Kai Felbel, Dominik Paukovitsch, Michael Schneider, Leonhard Moritz Markovic, Sinisa Rottbauer, Wolfgang Keßler, Mirjam J Clin Med Article Background: Improvement in concomitant tricuspid regurgitation (TR) after mitral valve transcatheter edge-to-edge repair (M-TEER) for mitral regurgitation (MR) occurs frequently; however factors determining the post-procedural course of TR are not well understood. We investigated the parameters associated with TR improvement after M-TEER. Methods and Results: A total of 300 patients were consecutively included in this retrospective analysis. MR and TR severity as well as heart chamber metrics were assessed before the procedure and at follow-up. Device success was achieved in 97.3% of patients. TR decreased in 30.2% of patients. Patients with improved TR were more often female, had more severe TR at baseline, and their right heart dimensions at baseline trended to be smaller. Female sex (odds ratio (OR) 2.997), baseline MR-Grade (OR 3.181) and baseline TR-Grade (OR 2.653) independently predicted TR reduction. More pronounced right heart reverse remodeling was observed in patients with improved TR. TR regression independently predicted lower mortality (hazard ratio (HR) 0.333, 95% confidence interval 0.112–0.996, p = 0.049). Conclusions: A reduction in concomitant TR severity after M-TEER occurred mainly in females and in patients with high-grade TR and MR at baseline. TR regression is associated with better survival after M-TEER. MDPI 2023-09-25 /pmc/articles/PMC10573471/ /pubmed/37834835 http://dx.doi.org/10.3390/jcm12196191 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gröger, Matthias
Hirsch, Kai
Felbel, Dominik
Paukovitsch, Michael
Schneider, Leonhard Moritz
Markovic, Sinisa
Rottbauer, Wolfgang
Keßler, Mirjam
Predictors of Improvement in Concomitant Tricuspid Regurgitation Following Transcatheter Edge-to-Edge Mitral Valve Repair
title Predictors of Improvement in Concomitant Tricuspid Regurgitation Following Transcatheter Edge-to-Edge Mitral Valve Repair
title_full Predictors of Improvement in Concomitant Tricuspid Regurgitation Following Transcatheter Edge-to-Edge Mitral Valve Repair
title_fullStr Predictors of Improvement in Concomitant Tricuspid Regurgitation Following Transcatheter Edge-to-Edge Mitral Valve Repair
title_full_unstemmed Predictors of Improvement in Concomitant Tricuspid Regurgitation Following Transcatheter Edge-to-Edge Mitral Valve Repair
title_short Predictors of Improvement in Concomitant Tricuspid Regurgitation Following Transcatheter Edge-to-Edge Mitral Valve Repair
title_sort predictors of improvement in concomitant tricuspid regurgitation following transcatheter edge-to-edge mitral valve repair
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573471/
https://www.ncbi.nlm.nih.gov/pubmed/37834835
http://dx.doi.org/10.3390/jcm12196191
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