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Consequences of Disturbing Manganese Homeostasis

Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant enzyme systems, neurotransmitter production, and the regulation of reproductive hormones. However, overexposure to Mn is to...

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Autores principales: Baj, Jacek, Flieger, Wojciech, Barbachowska, Aleksandra, Kowalska, Beata, Flieger, Michał, Forma, Alicja, Teresiński, Grzegorz, Portincasa, Piero, Buszewicz, Grzegorz, Radzikowska-Büchner, Elżbieta, Flieger, Jolanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573482/
https://www.ncbi.nlm.nih.gov/pubmed/37834407
http://dx.doi.org/10.3390/ijms241914959
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author Baj, Jacek
Flieger, Wojciech
Barbachowska, Aleksandra
Kowalska, Beata
Flieger, Michał
Forma, Alicja
Teresiński, Grzegorz
Portincasa, Piero
Buszewicz, Grzegorz
Radzikowska-Büchner, Elżbieta
Flieger, Jolanta
author_facet Baj, Jacek
Flieger, Wojciech
Barbachowska, Aleksandra
Kowalska, Beata
Flieger, Michał
Forma, Alicja
Teresiński, Grzegorz
Portincasa, Piero
Buszewicz, Grzegorz
Radzikowska-Büchner, Elżbieta
Flieger, Jolanta
author_sort Baj, Jacek
collection PubMed
description Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant enzyme systems, neurotransmitter production, and the regulation of reproductive hormones. However, overexposure to Mn is toxic, particularly to the central nervous system (CNS) due to it causing the progressive destruction of nerve cells. Exposure to manganese is widespread and occurs by inhalation, ingestion, or dermal contact. Associations have been observed between Mn accumulation and neurodegenerative diseases such as manganism, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. People with genetic diseases associated with a mutation in the gene associated with impaired Mn excretion, kidney disease, iron deficiency, or a vegetarian diet are at particular risk of excessive exposure to Mn. This review has collected data on the current knowledge of the source of Mn exposure, the experimental data supporting the dispersive accumulation of Mn in the brain, the controversies surrounding the reference values of biomarkers related to Mn status in different matrices, and the competitiveness of Mn with other metals, such as iron (Fe), magnesium (Mg), zinc (Zn), copper (Cu), lead (Pb), calcium (Ca). The disturbed homeostasis of Mn in the body has been connected with susceptibility to neurodegenerative diseases, fertility, and infectious diseases. The current evidence on the involvement of Mn in metabolic diseases, such as type 2 diabetes mellitus/insulin resistance, osteoporosis, obesity, atherosclerosis, and non-alcoholic fatty liver disease, was collected and discussed.
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spelling pubmed-105734822023-10-14 Consequences of Disturbing Manganese Homeostasis Baj, Jacek Flieger, Wojciech Barbachowska, Aleksandra Kowalska, Beata Flieger, Michał Forma, Alicja Teresiński, Grzegorz Portincasa, Piero Buszewicz, Grzegorz Radzikowska-Büchner, Elżbieta Flieger, Jolanta Int J Mol Sci Review Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant enzyme systems, neurotransmitter production, and the regulation of reproductive hormones. However, overexposure to Mn is toxic, particularly to the central nervous system (CNS) due to it causing the progressive destruction of nerve cells. Exposure to manganese is widespread and occurs by inhalation, ingestion, or dermal contact. Associations have been observed between Mn accumulation and neurodegenerative diseases such as manganism, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. People with genetic diseases associated with a mutation in the gene associated with impaired Mn excretion, kidney disease, iron deficiency, or a vegetarian diet are at particular risk of excessive exposure to Mn. This review has collected data on the current knowledge of the source of Mn exposure, the experimental data supporting the dispersive accumulation of Mn in the brain, the controversies surrounding the reference values of biomarkers related to Mn status in different matrices, and the competitiveness of Mn with other metals, such as iron (Fe), magnesium (Mg), zinc (Zn), copper (Cu), lead (Pb), calcium (Ca). The disturbed homeostasis of Mn in the body has been connected with susceptibility to neurodegenerative diseases, fertility, and infectious diseases. The current evidence on the involvement of Mn in metabolic diseases, such as type 2 diabetes mellitus/insulin resistance, osteoporosis, obesity, atherosclerosis, and non-alcoholic fatty liver disease, was collected and discussed. MDPI 2023-10-06 /pmc/articles/PMC10573482/ /pubmed/37834407 http://dx.doi.org/10.3390/ijms241914959 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Baj, Jacek
Flieger, Wojciech
Barbachowska, Aleksandra
Kowalska, Beata
Flieger, Michał
Forma, Alicja
Teresiński, Grzegorz
Portincasa, Piero
Buszewicz, Grzegorz
Radzikowska-Büchner, Elżbieta
Flieger, Jolanta
Consequences of Disturbing Manganese Homeostasis
title Consequences of Disturbing Manganese Homeostasis
title_full Consequences of Disturbing Manganese Homeostasis
title_fullStr Consequences of Disturbing Manganese Homeostasis
title_full_unstemmed Consequences of Disturbing Manganese Homeostasis
title_short Consequences of Disturbing Manganese Homeostasis
title_sort consequences of disturbing manganese homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573482/
https://www.ncbi.nlm.nih.gov/pubmed/37834407
http://dx.doi.org/10.3390/ijms241914959
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