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Metallic Nanoparticles: A Promising Arsenal against Antimicrobial Resistance—Unraveling Mechanisms and Enhancing Medication Efficacy

The misuse of antibiotics and antimycotics accelerates the emergence of antimicrobial resistance, prompting the need for novel strategies to combat this global issue. Metallic nanoparticles have emerged as effective tools for combating various resistant microbes. Numerous studies have highlighted th...

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Detalles Bibliográficos
Autores principales: Wahab, Shahid, Salman, Alishba, Khan, Zaryab, Khan, Sadia, Krishnaraj, Chandran, Yun, Soon-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573543/
https://www.ncbi.nlm.nih.gov/pubmed/37834344
http://dx.doi.org/10.3390/ijms241914897
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author Wahab, Shahid
Salman, Alishba
Khan, Zaryab
Khan, Sadia
Krishnaraj, Chandran
Yun, Soon-Il
author_facet Wahab, Shahid
Salman, Alishba
Khan, Zaryab
Khan, Sadia
Krishnaraj, Chandran
Yun, Soon-Il
author_sort Wahab, Shahid
collection PubMed
description The misuse of antibiotics and antimycotics accelerates the emergence of antimicrobial resistance, prompting the need for novel strategies to combat this global issue. Metallic nanoparticles have emerged as effective tools for combating various resistant microbes. Numerous studies have highlighted their potential in addressing antibiotic-resistant fungi and bacterial strains. Understanding the mechanisms of action of these nanoparticles, including iron-oxide, gold, zinc oxide, and silver is a central focus of research within the life science community. Various hypotheses have been proposed regarding how nanoparticles exert their effects. Some suggest direct targeting of microbial cell membranes, while others emphasize the release of ions from nanoparticles. The most compelling proposed antimicrobial mechanism of nanoparticles involves oxidative damage caused by nanoparticles-generated reactive oxygen species. This review aims to consolidate knowledge, discuss the properties and mechanisms of action of metallic nanoparticles, and underscore their potential as alternatives to enhance the efficacy of existing medications against infections caused by antimicrobial-resistant pathogens.
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spelling pubmed-105735432023-10-14 Metallic Nanoparticles: A Promising Arsenal against Antimicrobial Resistance—Unraveling Mechanisms and Enhancing Medication Efficacy Wahab, Shahid Salman, Alishba Khan, Zaryab Khan, Sadia Krishnaraj, Chandran Yun, Soon-Il Int J Mol Sci Review The misuse of antibiotics and antimycotics accelerates the emergence of antimicrobial resistance, prompting the need for novel strategies to combat this global issue. Metallic nanoparticles have emerged as effective tools for combating various resistant microbes. Numerous studies have highlighted their potential in addressing antibiotic-resistant fungi and bacterial strains. Understanding the mechanisms of action of these nanoparticles, including iron-oxide, gold, zinc oxide, and silver is a central focus of research within the life science community. Various hypotheses have been proposed regarding how nanoparticles exert their effects. Some suggest direct targeting of microbial cell membranes, while others emphasize the release of ions from nanoparticles. The most compelling proposed antimicrobial mechanism of nanoparticles involves oxidative damage caused by nanoparticles-generated reactive oxygen species. This review aims to consolidate knowledge, discuss the properties and mechanisms of action of metallic nanoparticles, and underscore their potential as alternatives to enhance the efficacy of existing medications against infections caused by antimicrobial-resistant pathogens. MDPI 2023-10-04 /pmc/articles/PMC10573543/ /pubmed/37834344 http://dx.doi.org/10.3390/ijms241914897 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wahab, Shahid
Salman, Alishba
Khan, Zaryab
Khan, Sadia
Krishnaraj, Chandran
Yun, Soon-Il
Metallic Nanoparticles: A Promising Arsenal against Antimicrobial Resistance—Unraveling Mechanisms and Enhancing Medication Efficacy
title Metallic Nanoparticles: A Promising Arsenal against Antimicrobial Resistance—Unraveling Mechanisms and Enhancing Medication Efficacy
title_full Metallic Nanoparticles: A Promising Arsenal against Antimicrobial Resistance—Unraveling Mechanisms and Enhancing Medication Efficacy
title_fullStr Metallic Nanoparticles: A Promising Arsenal against Antimicrobial Resistance—Unraveling Mechanisms and Enhancing Medication Efficacy
title_full_unstemmed Metallic Nanoparticles: A Promising Arsenal against Antimicrobial Resistance—Unraveling Mechanisms and Enhancing Medication Efficacy
title_short Metallic Nanoparticles: A Promising Arsenal against Antimicrobial Resistance—Unraveling Mechanisms and Enhancing Medication Efficacy
title_sort metallic nanoparticles: a promising arsenal against antimicrobial resistance—unraveling mechanisms and enhancing medication efficacy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573543/
https://www.ncbi.nlm.nih.gov/pubmed/37834344
http://dx.doi.org/10.3390/ijms241914897
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