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Management of Constipation in Hospitalized Patients
Constipation is frequently encountered in hospital settings and can have potentially serious consequences yet is often underrecognized and undertreated. Opioid-induced constipation is a common cause of constipation in hospitalized patients. Opioids induce constipation through agonistic effects on en...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573544/ https://www.ncbi.nlm.nih.gov/pubmed/37834791 http://dx.doi.org/10.3390/jcm12196148 |
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author | Sayuk, Gregory S. Yu, Qi T. Shy, Corey |
author_facet | Sayuk, Gregory S. Yu, Qi T. Shy, Corey |
author_sort | Sayuk, Gregory S. |
collection | PubMed |
description | Constipation is frequently encountered in hospital settings and can have potentially serious consequences yet is often underrecognized and undertreated. Opioid-induced constipation is a common cause of constipation in hospitalized patients. Opioids induce constipation through agonistic effects on enteric µ-opioid receptors. This review aims to provide insight on the identification and management of constipation in inpatient settings, with a particular focus on opioid-induced constipation. Constipation assessment should be routinely initiated at hospital admission and can be facilitated by thorough symptom assessments; relevant patient history, including recent medication use; physical examination; and patient assessment tools developed to evaluate the impact of constipation. Management of opioid-induced constipation should begin with ensuring adequate hydration and electrolyte balance and encouraging patient mobilization. Other treatments may include laxatives, enemas, intestinal secretagogues, peripherally acting µ-opioid receptor antagonists, and manual disimpaction. Surgical intervention may be required for some patients as a salvage therapy in severe, refractory cases. |
format | Online Article Text |
id | pubmed-10573544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105735442023-10-14 Management of Constipation in Hospitalized Patients Sayuk, Gregory S. Yu, Qi T. Shy, Corey J Clin Med Review Constipation is frequently encountered in hospital settings and can have potentially serious consequences yet is often underrecognized and undertreated. Opioid-induced constipation is a common cause of constipation in hospitalized patients. Opioids induce constipation through agonistic effects on enteric µ-opioid receptors. This review aims to provide insight on the identification and management of constipation in inpatient settings, with a particular focus on opioid-induced constipation. Constipation assessment should be routinely initiated at hospital admission and can be facilitated by thorough symptom assessments; relevant patient history, including recent medication use; physical examination; and patient assessment tools developed to evaluate the impact of constipation. Management of opioid-induced constipation should begin with ensuring adequate hydration and electrolyte balance and encouraging patient mobilization. Other treatments may include laxatives, enemas, intestinal secretagogues, peripherally acting µ-opioid receptor antagonists, and manual disimpaction. Surgical intervention may be required for some patients as a salvage therapy in severe, refractory cases. MDPI 2023-09-23 /pmc/articles/PMC10573544/ /pubmed/37834791 http://dx.doi.org/10.3390/jcm12196148 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sayuk, Gregory S. Yu, Qi T. Shy, Corey Management of Constipation in Hospitalized Patients |
title | Management of Constipation in Hospitalized Patients |
title_full | Management of Constipation in Hospitalized Patients |
title_fullStr | Management of Constipation in Hospitalized Patients |
title_full_unstemmed | Management of Constipation in Hospitalized Patients |
title_short | Management of Constipation in Hospitalized Patients |
title_sort | management of constipation in hospitalized patients |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573544/ https://www.ncbi.nlm.nih.gov/pubmed/37834791 http://dx.doi.org/10.3390/jcm12196148 |
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