Cargando…
Conjunctival Limbal Autograft Combined with Amnion-Assisted Conjunctival Epithelial Redirection for Unilateral Total Limbal Stem Cell Deficiency after Severe Chemical Burn
(1) Background: To evaluate the efficacy of conjunctival limbal autograft (CLAU) combined with the amnion-assisted conjunctival epithelial redirection (ACER) procedure for patients with unilateral total limbal stem cell deficiency (LSCD) caused by severe chemical burn. (2) Methods: A retrospective i...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573734/ https://www.ncbi.nlm.nih.gov/pubmed/37834878 http://dx.doi.org/10.3390/jcm12196235 |
_version_ | 1785120531305988096 |
---|---|
author | Yao, Tian-Yu Wang, Jia-Song Geng, Wen Xie, Hua-Tao Zhang, Ming-Chang |
author_facet | Yao, Tian-Yu Wang, Jia-Song Geng, Wen Xie, Hua-Tao Zhang, Ming-Chang |
author_sort | Yao, Tian-Yu |
collection | PubMed |
description | (1) Background: To evaluate the efficacy of conjunctival limbal autograft (CLAU) combined with the amnion-assisted conjunctival epithelial redirection (ACER) procedure for patients with unilateral total limbal stem cell deficiency (LSCD) caused by severe chemical burn. (2) Methods: A retrospective interventional case series of unilateral total LSCD after chemical burn who underwent CLAU combined with ACER surgery between September 2021 and July 2023 was collected. Outcome measures included epithelialization of the cornea with donor limbus-derived epithelium, best corrected visual acuity (BCVA), and complications. (3) Results: Nine males and one female were included in this study. The mean age was 40.9 ± 9.63 (range, 26 to 55) years. The average duration between injury and CLAU combined with the ACER procedure was 7.67 ± 3.97 (range, 4 to 18) months. All patients achieved corneal epithelialization and improved BCVA. Postoperative complications occurred in four cases, including delayed corneal epithelial healing in one case, delayed amniotic membrane dissolution and detachment in two cases, and recurrence of symblepharon in one case. No complications were noted in the healthy donor eyes. (4) Conclusions: CLAU combined with ACER is a safe and effective treatment for unilateral total LSCD caused by severe chemical burn. This combined surgery restores visual function for patients with corneal blindness caused by chemical burn, reducing the burden on the families and society. |
format | Online Article Text |
id | pubmed-10573734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105737342023-10-14 Conjunctival Limbal Autograft Combined with Amnion-Assisted Conjunctival Epithelial Redirection for Unilateral Total Limbal Stem Cell Deficiency after Severe Chemical Burn Yao, Tian-Yu Wang, Jia-Song Geng, Wen Xie, Hua-Tao Zhang, Ming-Chang J Clin Med Article (1) Background: To evaluate the efficacy of conjunctival limbal autograft (CLAU) combined with the amnion-assisted conjunctival epithelial redirection (ACER) procedure for patients with unilateral total limbal stem cell deficiency (LSCD) caused by severe chemical burn. (2) Methods: A retrospective interventional case series of unilateral total LSCD after chemical burn who underwent CLAU combined with ACER surgery between September 2021 and July 2023 was collected. Outcome measures included epithelialization of the cornea with donor limbus-derived epithelium, best corrected visual acuity (BCVA), and complications. (3) Results: Nine males and one female were included in this study. The mean age was 40.9 ± 9.63 (range, 26 to 55) years. The average duration between injury and CLAU combined with the ACER procedure was 7.67 ± 3.97 (range, 4 to 18) months. All patients achieved corneal epithelialization and improved BCVA. Postoperative complications occurred in four cases, including delayed corneal epithelial healing in one case, delayed amniotic membrane dissolution and detachment in two cases, and recurrence of symblepharon in one case. No complications were noted in the healthy donor eyes. (4) Conclusions: CLAU combined with ACER is a safe and effective treatment for unilateral total LSCD caused by severe chemical burn. This combined surgery restores visual function for patients with corneal blindness caused by chemical burn, reducing the burden on the families and society. MDPI 2023-09-27 /pmc/articles/PMC10573734/ /pubmed/37834878 http://dx.doi.org/10.3390/jcm12196235 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yao, Tian-Yu Wang, Jia-Song Geng, Wen Xie, Hua-Tao Zhang, Ming-Chang Conjunctival Limbal Autograft Combined with Amnion-Assisted Conjunctival Epithelial Redirection for Unilateral Total Limbal Stem Cell Deficiency after Severe Chemical Burn |
title | Conjunctival Limbal Autograft Combined with Amnion-Assisted Conjunctival Epithelial Redirection for Unilateral Total Limbal Stem Cell Deficiency after Severe Chemical Burn |
title_full | Conjunctival Limbal Autograft Combined with Amnion-Assisted Conjunctival Epithelial Redirection for Unilateral Total Limbal Stem Cell Deficiency after Severe Chemical Burn |
title_fullStr | Conjunctival Limbal Autograft Combined with Amnion-Assisted Conjunctival Epithelial Redirection for Unilateral Total Limbal Stem Cell Deficiency after Severe Chemical Burn |
title_full_unstemmed | Conjunctival Limbal Autograft Combined with Amnion-Assisted Conjunctival Epithelial Redirection for Unilateral Total Limbal Stem Cell Deficiency after Severe Chemical Burn |
title_short | Conjunctival Limbal Autograft Combined with Amnion-Assisted Conjunctival Epithelial Redirection for Unilateral Total Limbal Stem Cell Deficiency after Severe Chemical Burn |
title_sort | conjunctival limbal autograft combined with amnion-assisted conjunctival epithelial redirection for unilateral total limbal stem cell deficiency after severe chemical burn |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573734/ https://www.ncbi.nlm.nih.gov/pubmed/37834878 http://dx.doi.org/10.3390/jcm12196235 |
work_keys_str_mv | AT yaotianyu conjunctivallimbalautograftcombinedwithamnionassistedconjunctivalepithelialredirectionforunilateraltotallimbalstemcelldeficiencyafterseverechemicalburn AT wangjiasong conjunctivallimbalautograftcombinedwithamnionassistedconjunctivalepithelialredirectionforunilateraltotallimbalstemcelldeficiencyafterseverechemicalburn AT gengwen conjunctivallimbalautograftcombinedwithamnionassistedconjunctivalepithelialredirectionforunilateraltotallimbalstemcelldeficiencyafterseverechemicalburn AT xiehuatao conjunctivallimbalautograftcombinedwithamnionassistedconjunctivalepithelialredirectionforunilateraltotallimbalstemcelldeficiencyafterseverechemicalburn AT zhangmingchang conjunctivallimbalautograftcombinedwithamnionassistedconjunctivalepithelialredirectionforunilateraltotallimbalstemcelldeficiencyafterseverechemicalburn |