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Electrochemotherapy in the Treatment of Bone Metastases: A Systematic Review

Background and aim: Cancers are one of the most frequent causes of death and disability in humans. Skeletal involvement has a major impact on the quality of life and prognosis of cancer patients. Electrochemotherapy is a palliative and minimally invasive oncologic treatment that was first used to tr...

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Autores principales: Bocchi, Maria Beatrice, Meschini, Cesare, Pietramala, Silvia, Perna, Andrea, Oliva, Maria Serena, Matrangolo, Maria Rosaria, Ziranu, Antonio, Maccauro, Giulio, Vitiello, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573742/
https://www.ncbi.nlm.nih.gov/pubmed/37834793
http://dx.doi.org/10.3390/jcm12196150
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author Bocchi, Maria Beatrice
Meschini, Cesare
Pietramala, Silvia
Perna, Andrea
Oliva, Maria Serena
Matrangolo, Maria Rosaria
Ziranu, Antonio
Maccauro, Giulio
Vitiello, Raffaele
author_facet Bocchi, Maria Beatrice
Meschini, Cesare
Pietramala, Silvia
Perna, Andrea
Oliva, Maria Serena
Matrangolo, Maria Rosaria
Ziranu, Antonio
Maccauro, Giulio
Vitiello, Raffaele
author_sort Bocchi, Maria Beatrice
collection PubMed
description Background and aim: Cancers are one of the most frequent causes of death and disability in humans. Skeletal involvement has a major impact on the quality of life and prognosis of cancer patients. Electrochemotherapy is a palliative and minimally invasive oncologic treatment that was first used to treat subcutaneous nodules for malignant tumors. The aim of our review is to evaluate the results of electrochemotherapy in the treatment of bone metastases. Methods: A systematic review of the literature indexed in the PubMed MEDLINE and Cochrane Library databases using the search key words “electrochemotherapy” AND (“metastasis” OR “metastases”) was performed. The Preferred Reporting Items for Systematic Reviews and MetaAnalyses was followed. Inclusion criteria were proven involvement of the appendicular skeleton in metastatic carcinoma or melanoma, through at least one percutaneous electrochemotherapy session on the metastatic bone lesion. The exclusion criterion was no skeletal metastatic involvement. Results: Eight articles were finally included. We reached a population of 246 patients. The mean age and follow up were 60.1 years old and 11.4 months, respectively. The most represented primary tumor was breast cancer (18.9%). A total of 250 bone lesions were treated with electrochemotherapy. According to RECIST criteria, in our population we observed 55.5% stable diseases. The mean pre-electrochemotherapy VAS value was 6.9, which lowered to 2.7 after treatment. Adverse events occurred in 3.4% of patients. Conclusions: Electrochemotherapy as a minimally invasive and tissue-sparing treatment should be considered for patients with no other alternative to obtain tumor control and improvement in quality of life.
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spelling pubmed-105737422023-10-14 Electrochemotherapy in the Treatment of Bone Metastases: A Systematic Review Bocchi, Maria Beatrice Meschini, Cesare Pietramala, Silvia Perna, Andrea Oliva, Maria Serena Matrangolo, Maria Rosaria Ziranu, Antonio Maccauro, Giulio Vitiello, Raffaele J Clin Med Systematic Review Background and aim: Cancers are one of the most frequent causes of death and disability in humans. Skeletal involvement has a major impact on the quality of life and prognosis of cancer patients. Electrochemotherapy is a palliative and minimally invasive oncologic treatment that was first used to treat subcutaneous nodules for malignant tumors. The aim of our review is to evaluate the results of electrochemotherapy in the treatment of bone metastases. Methods: A systematic review of the literature indexed in the PubMed MEDLINE and Cochrane Library databases using the search key words “electrochemotherapy” AND (“metastasis” OR “metastases”) was performed. The Preferred Reporting Items for Systematic Reviews and MetaAnalyses was followed. Inclusion criteria were proven involvement of the appendicular skeleton in metastatic carcinoma or melanoma, through at least one percutaneous electrochemotherapy session on the metastatic bone lesion. The exclusion criterion was no skeletal metastatic involvement. Results: Eight articles were finally included. We reached a population of 246 patients. The mean age and follow up were 60.1 years old and 11.4 months, respectively. The most represented primary tumor was breast cancer (18.9%). A total of 250 bone lesions were treated with electrochemotherapy. According to RECIST criteria, in our population we observed 55.5% stable diseases. The mean pre-electrochemotherapy VAS value was 6.9, which lowered to 2.7 after treatment. Adverse events occurred in 3.4% of patients. Conclusions: Electrochemotherapy as a minimally invasive and tissue-sparing treatment should be considered for patients with no other alternative to obtain tumor control and improvement in quality of life. MDPI 2023-09-23 /pmc/articles/PMC10573742/ /pubmed/37834793 http://dx.doi.org/10.3390/jcm12196150 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Bocchi, Maria Beatrice
Meschini, Cesare
Pietramala, Silvia
Perna, Andrea
Oliva, Maria Serena
Matrangolo, Maria Rosaria
Ziranu, Antonio
Maccauro, Giulio
Vitiello, Raffaele
Electrochemotherapy in the Treatment of Bone Metastases: A Systematic Review
title Electrochemotherapy in the Treatment of Bone Metastases: A Systematic Review
title_full Electrochemotherapy in the Treatment of Bone Metastases: A Systematic Review
title_fullStr Electrochemotherapy in the Treatment of Bone Metastases: A Systematic Review
title_full_unstemmed Electrochemotherapy in the Treatment of Bone Metastases: A Systematic Review
title_short Electrochemotherapy in the Treatment of Bone Metastases: A Systematic Review
title_sort electrochemotherapy in the treatment of bone metastases: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573742/
https://www.ncbi.nlm.nih.gov/pubmed/37834793
http://dx.doi.org/10.3390/jcm12196150
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