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Pharmacokinetic Model-Based Control across the Blood–Brain Barrier for Circadian Entrainment
The ability to shift circadian phase in vivo has the potential to offer substantial health benefits. However, the blood–brain barrier prevents the absorption of the majority of large and many small molecules, posing a challenge to neurological pharmaceutical development. Motivated by the presence of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573769/ https://www.ncbi.nlm.nih.gov/pubmed/37834278 http://dx.doi.org/10.3390/ijms241914830 |