Three-Dimensional Modeling of CpG DNA Binding with Matrix Lumican Shows Leucine-Rich Repeat Motif Involvement as in TLR9-CpG DNA Interactions

Lumican is an extracellular matrix proteoglycan known to regulate toll-like receptor (TLR) signaling in innate immune cells. In experimental settings, lumican suppresses TLR9 signaling by binding to and sequestering its synthetic ligand, CpG-DNA, in non-signal permissive endosomes. However, the mole...

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Detalles Bibliográficos
Autores principales: Choi, Tansol, Maiti, George, Chakravarti, Shukti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573802/
https://www.ncbi.nlm.nih.gov/pubmed/37834438
http://dx.doi.org/10.3390/ijms241914990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573802/
https://www.ncbi.nlm.nih.gov/pubmed/37834438
http://dx.doi.org/10.3390/ijms241914990

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