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Efferocytosis and Respiratory Disease
Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis. If...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573909/ https://www.ncbi.nlm.nih.gov/pubmed/37834319 http://dx.doi.org/10.3390/ijms241914871 |
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author | Zheng, Wenxue Zhou, Zhengjie Guo, Xiaoping Zuo, Xu Zhang, Jiaqi An, Yiming Zheng, Haoyu Yue, Yuan Wang, Guoqiang Wang, Fang |
author_facet | Zheng, Wenxue Zhou, Zhengjie Guo, Xiaoping Zuo, Xu Zhang, Jiaqi An, Yiming Zheng, Haoyu Yue, Yuan Wang, Guoqiang Wang, Fang |
author_sort | Zheng, Wenxue |
collection | PubMed |
description | Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis. If the process fails, this may cause different types of diseases. More and more evidence suggests that a faulty efferocytosis process is closely related to the pathological processes of respiratory diseases. In this review, we will first introduce the process and the related mechanisms of efferocytosis of the macrophage. Secondly, we will propose some methods that can regulate the function of efferocytosis at different stages of the process. Next, we will discuss the role of efferocytosis in different lung diseases and the related treatment approaches. Finally, we will summarize the drugs that have been applied in clinical practice that can act upon efferocytosis, in order to provide new ideas for the treatment of lung diseases. |
format | Online Article Text |
id | pubmed-10573909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105739092023-10-14 Efferocytosis and Respiratory Disease Zheng, Wenxue Zhou, Zhengjie Guo, Xiaoping Zuo, Xu Zhang, Jiaqi An, Yiming Zheng, Haoyu Yue, Yuan Wang, Guoqiang Wang, Fang Int J Mol Sci Review Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis. If the process fails, this may cause different types of diseases. More and more evidence suggests that a faulty efferocytosis process is closely related to the pathological processes of respiratory diseases. In this review, we will first introduce the process and the related mechanisms of efferocytosis of the macrophage. Secondly, we will propose some methods that can regulate the function of efferocytosis at different stages of the process. Next, we will discuss the role of efferocytosis in different lung diseases and the related treatment approaches. Finally, we will summarize the drugs that have been applied in clinical practice that can act upon efferocytosis, in order to provide new ideas for the treatment of lung diseases. MDPI 2023-10-03 /pmc/articles/PMC10573909/ /pubmed/37834319 http://dx.doi.org/10.3390/ijms241914871 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zheng, Wenxue Zhou, Zhengjie Guo, Xiaoping Zuo, Xu Zhang, Jiaqi An, Yiming Zheng, Haoyu Yue, Yuan Wang, Guoqiang Wang, Fang Efferocytosis and Respiratory Disease |
title | Efferocytosis and Respiratory Disease |
title_full | Efferocytosis and Respiratory Disease |
title_fullStr | Efferocytosis and Respiratory Disease |
title_full_unstemmed | Efferocytosis and Respiratory Disease |
title_short | Efferocytosis and Respiratory Disease |
title_sort | efferocytosis and respiratory disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573909/ https://www.ncbi.nlm.nih.gov/pubmed/37834319 http://dx.doi.org/10.3390/ijms241914871 |
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