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Efferocytosis and Respiratory Disease

Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis. If...

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Autores principales: Zheng, Wenxue, Zhou, Zhengjie, Guo, Xiaoping, Zuo, Xu, Zhang, Jiaqi, An, Yiming, Zheng, Haoyu, Yue, Yuan, Wang, Guoqiang, Wang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573909/
https://www.ncbi.nlm.nih.gov/pubmed/37834319
http://dx.doi.org/10.3390/ijms241914871
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author Zheng, Wenxue
Zhou, Zhengjie
Guo, Xiaoping
Zuo, Xu
Zhang, Jiaqi
An, Yiming
Zheng, Haoyu
Yue, Yuan
Wang, Guoqiang
Wang, Fang
author_facet Zheng, Wenxue
Zhou, Zhengjie
Guo, Xiaoping
Zuo, Xu
Zhang, Jiaqi
An, Yiming
Zheng, Haoyu
Yue, Yuan
Wang, Guoqiang
Wang, Fang
author_sort Zheng, Wenxue
collection PubMed
description Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis. If the process fails, this may cause different types of diseases. More and more evidence suggests that a faulty efferocytosis process is closely related to the pathological processes of respiratory diseases. In this review, we will first introduce the process and the related mechanisms of efferocytosis of the macrophage. Secondly, we will propose some methods that can regulate the function of efferocytosis at different stages of the process. Next, we will discuss the role of efferocytosis in different lung diseases and the related treatment approaches. Finally, we will summarize the drugs that have been applied in clinical practice that can act upon efferocytosis, in order to provide new ideas for the treatment of lung diseases.
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spelling pubmed-105739092023-10-14 Efferocytosis and Respiratory Disease Zheng, Wenxue Zhou, Zhengjie Guo, Xiaoping Zuo, Xu Zhang, Jiaqi An, Yiming Zheng, Haoyu Yue, Yuan Wang, Guoqiang Wang, Fang Int J Mol Sci Review Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis. If the process fails, this may cause different types of diseases. More and more evidence suggests that a faulty efferocytosis process is closely related to the pathological processes of respiratory diseases. In this review, we will first introduce the process and the related mechanisms of efferocytosis of the macrophage. Secondly, we will propose some methods that can regulate the function of efferocytosis at different stages of the process. Next, we will discuss the role of efferocytosis in different lung diseases and the related treatment approaches. Finally, we will summarize the drugs that have been applied in clinical practice that can act upon efferocytosis, in order to provide new ideas for the treatment of lung diseases. MDPI 2023-10-03 /pmc/articles/PMC10573909/ /pubmed/37834319 http://dx.doi.org/10.3390/ijms241914871 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zheng, Wenxue
Zhou, Zhengjie
Guo, Xiaoping
Zuo, Xu
Zhang, Jiaqi
An, Yiming
Zheng, Haoyu
Yue, Yuan
Wang, Guoqiang
Wang, Fang
Efferocytosis and Respiratory Disease
title Efferocytosis and Respiratory Disease
title_full Efferocytosis and Respiratory Disease
title_fullStr Efferocytosis and Respiratory Disease
title_full_unstemmed Efferocytosis and Respiratory Disease
title_short Efferocytosis and Respiratory Disease
title_sort efferocytosis and respiratory disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573909/
https://www.ncbi.nlm.nih.gov/pubmed/37834319
http://dx.doi.org/10.3390/ijms241914871
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