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MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer’s Disease

Glaucoma is the leading cause of blindness worldwide. It is classically associated with structural and functional changes in the optic nerve head and retinal nerve fiber layer, but the damage is not limited to the eye. The involvement of the central visual pathways and disruption of brain network or...

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Autores principales: Martucci, Alessio, Di Giuliano, Francesca, Minosse, Silvia, Pocobelli, Giulio, Nucci, Carlo, Garaci, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573932/
https://www.ncbi.nlm.nih.gov/pubmed/37834380
http://dx.doi.org/10.3390/ijms241914932
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author Martucci, Alessio
Di Giuliano, Francesca
Minosse, Silvia
Pocobelli, Giulio
Nucci, Carlo
Garaci, Francesco
author_facet Martucci, Alessio
Di Giuliano, Francesca
Minosse, Silvia
Pocobelli, Giulio
Nucci, Carlo
Garaci, Francesco
author_sort Martucci, Alessio
collection PubMed
description Glaucoma is the leading cause of blindness worldwide. It is classically associated with structural and functional changes in the optic nerve head and retinal nerve fiber layer, but the damage is not limited to the eye. The involvement of the central visual pathways and disruption of brain network organization have been reported using advanced neuroimaging techniques. The brain structural changes at the level of the areas implied in processing visual information could justify the discrepancy between signs and symptoms and underlie the analogy of this disease with neurodegenerative dementias, such as Alzheimer’s disease, and with the complex group of pathologies commonly referred to as “disconnection syndromes.” This review aims to summarize the current state of the art on the use of advanced neuroimaging techniques in glaucoma and Alzheimer’s disease, highlighting the emerging biomarkers shared by both diseases.
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spelling pubmed-105739322023-10-14 MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer’s Disease Martucci, Alessio Di Giuliano, Francesca Minosse, Silvia Pocobelli, Giulio Nucci, Carlo Garaci, Francesco Int J Mol Sci Review Glaucoma is the leading cause of blindness worldwide. It is classically associated with structural and functional changes in the optic nerve head and retinal nerve fiber layer, but the damage is not limited to the eye. The involvement of the central visual pathways and disruption of brain network organization have been reported using advanced neuroimaging techniques. The brain structural changes at the level of the areas implied in processing visual information could justify the discrepancy between signs and symptoms and underlie the analogy of this disease with neurodegenerative dementias, such as Alzheimer’s disease, and with the complex group of pathologies commonly referred to as “disconnection syndromes.” This review aims to summarize the current state of the art on the use of advanced neuroimaging techniques in glaucoma and Alzheimer’s disease, highlighting the emerging biomarkers shared by both diseases. MDPI 2023-10-05 /pmc/articles/PMC10573932/ /pubmed/37834380 http://dx.doi.org/10.3390/ijms241914932 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martucci, Alessio
Di Giuliano, Francesca
Minosse, Silvia
Pocobelli, Giulio
Nucci, Carlo
Garaci, Francesco
MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer’s Disease
title MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer’s Disease
title_full MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer’s Disease
title_fullStr MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer’s Disease
title_full_unstemmed MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer’s Disease
title_short MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer’s Disease
title_sort mri and clinical biomarkers overlap between glaucoma and alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573932/
https://www.ncbi.nlm.nih.gov/pubmed/37834380
http://dx.doi.org/10.3390/ijms241914932
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