Cargando…

Diaphragm Fatigue in SMNΔ7 Mice and Its Molecular Determinants: An Underestimated Issue

Spinal muscular atrophy (SMA) is a genetic disorder characterized by the loss of spinal motor neurons leading to muscle weakness and respiratory failure. Mitochondrial dysfunctions are found in the skeletal muscle of patients with SMA. For obvious ethical reasons, the diaphragm muscle is poorly stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cadile, Francesca, Recchia, Deborah, Ansaldo, Massimiliano, Rossi, Paola, Rastelli, Giorgia, Boncompagni, Simona, Brocca, Lorenza, Pellegrino, Maria Antonietta, Canepari, Monica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574014/ https://www.ncbi.nlm.nih.gov/pubmed/37834400 http://dx.doi.org/10.3390/ijms241914953

Ejemplares similares

Exercise Preconditioning Blunts Early Atrogenes Expression and Atrophy in Gastrocnemius Muscle of Hindlimb Unloaded Mice
por: Brocca, Lorenza, et al.
Publicado: (2021)

Normalization of Patient-Identified Plasma Biomarkers in SMNΔ7 Mice following Postnatal SMN Restoration
por: Arnold, W. David, et al.
Publicado: (2016)

Lysine-Less Variants of Spinal Muscular Atrophy SMN and SMNΔ7 Proteins Are Degraded by the Proteasome Pathway
por: Sánchez-Lanzas, Raúl, et al.
Publicado: (2017)

Fatigue – an underestimated symptom in psoriatic arthritis
por: Krajewska-Włodarczyk, Magdalena, et al.
Publicado: (2017)

Constitutive assembly of Ca(2+) entry units in soleus muscle from calsequestrin knockout mice
por: Michelucci, Antonio, et al.
Publicado: (2022)

Diaphragm dysfunction during weaning from mechanical ventilation: an underestimated phenomenon with clinical implications
por: Dres, Martin, et al.
Publicado: (2018)

Cerebellar structural, astrocytic, and neuronal abnormalities in the SMNΔ7 mouse model of spinal muscular atrophy
por: Cottam, Nicholas C., et al.
Publicado: (2023)

Comorbidities in idiopathic pulmonary fibrosis: an underestimated issue
por: Caminati, Antonella, et al.
Publicado: (2019)

Significant diaphragm elevation suggestive of phrenic nerve injury after thoracoscopic lobectomy for lung cancer: an underestimated problem
por: Ventura, Luigi, et al.
Publicado: (2020)

Molecular Crosstalk Between Non-SMN-Related and SMN-Related Spinal Muscular Atrophy
por: Šoltić, Darija, et al.
Publicado: (2020)

A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II
por: Liu, Yanli, et al.
Publicado: (2022)

Alternative splicing of a cryptic exon embedded in intron 6 of SMN1 and SMN2
por: Yoshimoto, Satomi, et al.
Publicado: (2016)

CORRIGENDUM to Molecular Crosstalk Between Non-SMN-Related and SMN-Related Spinal Muscular Atrophy
Publicado: (2020)

The Need for SMN-Independent Treatments of Spinal Muscular Atrophy (SMA) to Complement SMN-Enhancing Drugs
por: Hensel, Niko, et al.
Publicado: (2020)

Diaphragm weakness and mechanical ventilation - what's the critical issue?
por: Callahan, Leigh Ann, et al.
Publicado: (2010)

PO(2) Cycling Reduces Diaphragm Fatigue by Attenuating ROS Formation
por: Zuo, Li, et al.
Publicado: (2014)

Effects of hypoxia on exercise‐induced diaphragm fatigue in healthy males and females
por: Reinhard, Paige A., et al.
Publicado: (2023)

Drug screening with human SMN2 reporter identifies SMN protein stabilizers to correct SMA pathology
por: Wang, Yiran, et al.
Publicado: (2019)

SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members
por: Binda, Olivier, et al.
Publicado: (2022)

The Frequency of SMN1, SMN2 Copy Numbers in 246 Turkish Cases Analyzed with MLPA Method
por: Yalcintepe, Sinem, et al.
Publicado: (2023)

Axon outgrowth and neuronal differentiation defects after a-SMN and FL-SMN silencing in primary hippocampal cultures
por: Pletto, Daniela, et al.
Publicado: (2018)

Numerical Simulation of Fatigue Cracking of Diaphragm Notch in Orthotropic Steel Deck Model
por: Zeng, Yong, et al.
Publicado: (2023)

Possible implication of undescribed SMN1-SMN2 genotype in chronic EMG-pattern of SMA with transitory acute denervation
por: Vitello, Girolamo A., et al.
Publicado: (2020)

NOVA1 promotes SMN2 exon 7 splicing by binding the UCAC motif and increases SMN protein expression
por: Du, Li-Li, et al.
Publicado: (2022)

Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA
por: Narcís, J. Oriol, et al.
Publicado: (2018)

Gastrointestinal neuromuscular apparatus: An underestimated target of gut microbiota
por: Guarino, Michele Pier Luca, et al.
Publicado: (2016)

Radial artery occlusion after percutaneous coronary interventions – an underestimated issue
por: Sławin, Janusz, et al.
Publicado: (2013)

Upregulation of PPARβ/δ Is Associated with Structural and Functional Changes in the Type I Diabetes Rat Diaphragm
por: Salvi, Nadège, et al.
Publicado: (2010)

Orai1-dependent Calcium Entry Promotes Skeletal Muscle Growth and Limits Fatigue
por: Wei-LaPierre, Lan, et al.
Publicado: (2013)

Smn-Deficiency Increases the Intrinsic Excitability of Motoneurons
por: Arumugam, Saravanan, et al.
Publicado: (2017)

Sumoylation regulates the assembly and activity of the SMN complex
por: Riboldi, Giulietta M., et al.
Publicado: (2021)

The Carrier Frequency of Two SMN1 Genes in Parents of Symptomatic Children with SMA and the Significance of SMN1 Exon 8 in Carriers
por: Davidson, Joanne E, et al.
Publicado: (2023)

Quantitative Analysis of SMN1 Gene and Estimation of SMN1 Deletion Carrier Frequency in Korean Population based on Real-Time PCR
por: Lee, Tae-Mi, et al.
Publicado: (2004)

Absence of an Intron Splicing Silencer in Porcine Smn1 Intron 7 Confers Immunity to the Exon Skipping Mutation in Human SMN2
por: Doktor, Thomas Koed, et al.
Publicado: (2014)

Molecular characterization and copy number of SMN1, SMN2 and NAIP in Chinese patients with spinal muscular atrophy and unrelated healthy controls
por: Fang, Ping, et al.
Publicado: (2015)

Genomic Variability in the Survival Motor Neuron Genes (SMN1 and SMN2): Implications for Spinal Muscular Atrophy Phenotype and Therapeutics Development
por: Butchbach, Matthew E. R.
Publicado: (2021)

Occupational Allergic Diseases in Kitchen and Health Care Workers: An Underestimated Health Issue
por: Bilge, Ugur, et al.
Publicado: (2013)

Assessment of Diaphragm and External Intercostals Fatigue from Surface EMG using Cervical Magnetic Stimulation
por: Chien, Meng-Yueh, et al.
Publicado: (2008)

Solution structure of the core SMN–Gemin2 complex
por: Sarachan, Kathryn L., et al.
Publicado: (2012)

Therapeutic strategies for spinal muscular atrophy: SMN and beyond
por: Bowerman, Melissa, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_igqh49rvnue745iqpq32h3oktg