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N-Acetylcysteine Displaces Glutathionyl-Moieties from Hg(2+) and MeHg(+) to Form More Hydrophobic Complexes at Near-Physiological Conditions

The anthropogenic release of Hg is associated with an increased human exposure risk. Since Hg(2+) and MeHg(+) have a high affinity for thiols, their interaction with L-glutathione (GSH) within mammalian cells is fundamentally involved in their toxicological chemistry and excretion. To gain insight i...

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Detalles Bibliográficos
Autores principales: Doroudian, Maryam, Thibault, Michelle E., Gailer, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574133/
https://www.ncbi.nlm.nih.gov/pubmed/37836605
http://dx.doi.org/10.3390/molecules28196762