Sabinene: A New Green Solvent Used in the Synthesis of Thiazolo[5,4-b]pyridines by Thermal or Microwave Activation

Following the work already carried out in our laboratory on eucalyptol, a new green solvent derived from biomass, we are now looking at sabinene as another new green solvent. Sabinene is also derived from biomass, has no known toxicity and can be recycled by distillation. We have shown that it can b...

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Autores principales: Messire, Gatien, Ferreira, Véronique, Caillet, Emma, Bodin, Lyana, Auville, Amélia, Berteina-Raboin, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574264/
https://www.ncbi.nlm.nih.gov/pubmed/37836766
http://dx.doi.org/10.3390/molecules28196924
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author Messire, Gatien
Ferreira, Véronique
Caillet, Emma
Bodin, Lyana
Auville, Amélia
Berteina-Raboin, Sabine
author_facet Messire, Gatien
Ferreira, Véronique
Caillet, Emma
Bodin, Lyana
Auville, Amélia
Berteina-Raboin, Sabine
author_sort Messire, Gatien
collection PubMed
description Following the work already carried out in our laboratory on eucalyptol, a new green solvent derived from biomass, we are now looking at sabinene as another new green solvent. Sabinene is also derived from biomass, has no known toxicity and can be recycled by distillation. We have shown that it can be used as it is or distilled to synthesize thiazolo[5,4-b]pyridine heterocycles by thermal activation or microwave irradiation. This new solvent was compared with various conventional and green solvents. The conditions were optimised to enable us to carry out the syntheses in satisfactory yields, and we were able to show that sabinene, a natural bicyclic monoterpene, could be used effectively as a solvent.
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spelling pubmed-105742642023-10-14 Sabinene: A New Green Solvent Used in the Synthesis of Thiazolo[5,4-b]pyridines by Thermal or Microwave Activation Messire, Gatien Ferreira, Véronique Caillet, Emma Bodin, Lyana Auville, Amélia Berteina-Raboin, Sabine Molecules Article Following the work already carried out in our laboratory on eucalyptol, a new green solvent derived from biomass, we are now looking at sabinene as another new green solvent. Sabinene is also derived from biomass, has no known toxicity and can be recycled by distillation. We have shown that it can be used as it is or distilled to synthesize thiazolo[5,4-b]pyridine heterocycles by thermal activation or microwave irradiation. This new solvent was compared with various conventional and green solvents. The conditions were optimised to enable us to carry out the syntheses in satisfactory yields, and we were able to show that sabinene, a natural bicyclic monoterpene, could be used effectively as a solvent. MDPI 2023-10-03 /pmc/articles/PMC10574264/ /pubmed/37836766 http://dx.doi.org/10.3390/molecules28196924 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Messire, Gatien
Ferreira, Véronique
Caillet, Emma
Bodin, Lyana
Auville, Amélia
Berteina-Raboin, Sabine
Sabinene: A New Green Solvent Used in the Synthesis of Thiazolo[5,4-b]pyridines by Thermal or Microwave Activation
title Sabinene: A New Green Solvent Used in the Synthesis of Thiazolo[5,4-b]pyridines by Thermal or Microwave Activation
title_full Sabinene: A New Green Solvent Used in the Synthesis of Thiazolo[5,4-b]pyridines by Thermal or Microwave Activation
title_fullStr Sabinene: A New Green Solvent Used in the Synthesis of Thiazolo[5,4-b]pyridines by Thermal or Microwave Activation
title_full_unstemmed Sabinene: A New Green Solvent Used in the Synthesis of Thiazolo[5,4-b]pyridines by Thermal or Microwave Activation
title_short Sabinene: A New Green Solvent Used in the Synthesis of Thiazolo[5,4-b]pyridines by Thermal or Microwave Activation
title_sort sabinene: a new green solvent used in the synthesis of thiazolo[5,4-b]pyridines by thermal or microwave activation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574264/
https://www.ncbi.nlm.nih.gov/pubmed/37836766
http://dx.doi.org/10.3390/molecules28196924
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