Cargando…

Unraveling the Therapeutic Mechanism of Saussurea involucrata against Rheumatoid Arthritis: A Network Pharmacology and Molecular Modeling-Based Investigation

Rheumatoid arthritis (RA) is a chronic autoimmune disease with a global prevalence of approximately 0.46%, causing significant impairments in patients’ quality of life and an economic burden. Saussurea involucrata (SI) has long been used in traditional medicine to treat RA, but its underlying mechan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jinghua, Wu, Xiaoke, Yu, Ruitao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574426/ https://www.ncbi.nlm.nih.gov/pubmed/37836578 http://dx.doi.org/10.3390/nu15194294

Ejemplares similares

Screening the components of Saussurea involucrata for novel targets for the treatment of NSCLC using network pharmacology
por: Zhang, Dongdong, et al.
Publicado: (2022)

Saussureae Involucratae Herba (Snow Lotus): Review of Chemical Compositions and Pharmacological Properties
por: Gong, Guowei, et al.
Publicado: (2020)

Exploring the possible molecular targeting mechanism of Saussurea involucrata in the treatment of COVID-19 based on bioinformatics and network pharmacology
por: Zhang, Dongdong, et al.
Publicado: (2022)

Antifatigue and Antioxidant Activity of Alcoholic Extract from Saussurea involucrata
por: Lee, Jang-Chang, et al.
Publicado: (2011)

Systems Pharmacology–Based Dissection of Anti-Cancer Mechanism of Traditional Chinese Herb Saussurea involucrata
por: Zhang, Qian, et al.
Publicado: (2021)

Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation
por: Wang, Lusheng, et al.
Publicado: (2023)

Metabolic Engineering of the Phenylpropanoid Pathway Enhances the Antioxidant Capacity of Saussurea involucrata
por: Qiu, Jian, et al.
Publicado: (2013)

Cloning and function analysis of a Saussurea involucrata LEA4 gene
por: Kong, Hui, et al.
Publicado: (2022)

Conservation Priorities and Demographic History of Saussurea involucrata in the Tianshan Mountains and Altai Mountains
por: Hu, Lin, et al.
Publicado: (2023)

Chemical Fingerprint Analysis for Discovering Markers and Identifying Saussurea involucrata by HPLC Coupled with OPLS-DA
por: Ma, Qingdong, et al.
Publicado: (2020)

In vitro culture and production of syringin and rutin in Saussurea involucrata (Kar. et Kir.) – an endangered medicinal plant
por: Kuo, Chao-Lin, et al.
Publicado: (2015)

De Novo Transcriptome Sequencing and the Hypothetical Cold Response Mode of Saussurea involucrata in Extreme Cold Environments
por: Li, Jin, et al.
Publicado: (2017)

Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants
por: Guo, Xinyong, et al.
Publicado: (2019)

Metabolites Analysis of Anti-Myocardial Ischemia Active Components of Saussurea involucrata Based on Gut Microbiota—Drug Interaction
por: Yu, Hang, et al.
Publicado: (2022)

Metabolomics-based exploration the response mechanisms of Saussurea involucrata leaves under different levels of low temperature stress
por: Sun, Qi, et al.
Publicado: (2023)

Rutin, a Flavonoid and Principal Component of Saussurea Involucrata, Attenuates Physical Fatigue in a Forced Swimming Mouse Model
por: Su, Kang-Yi, et al.
Publicado: (2014)

Genome assembly of the snow lotus species Saussurea involucrata provides insights into acacetin and rutin biosynthesis and tolerance to an alpine environment
por: Sun, Yanxia, et al.
Publicado: (2023)

Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model
por: Yang, Ying-Chen, et al.
Publicado: (2012)

Saussurea involucrata (Snow Lotus) ICE1 and ICE2 Orthologues Involved in Regulating Cold Stress Tolerance in Transgenic Arabidopsis
por: Wu, Chia-Ling, et al.
Publicado: (2021)

Anti-Melanogenesis Effect of Polysaccharide from Saussurea involucrata on Forskolin-Induced Melanogenesis in B16F10 Melanoma Cells
por: Kamilijiang, Mayila, et al.
Publicado: (2022)

Component Identification of Phenolic Acids in Cell Suspension Cultures of Saussurea involucrata and Its Mechanism of Anti-Hepatoma Revealed by TMT Quantitative Proteomics
por: Gao, Junpeng, et al.
Publicado: (2021)

Exploring the inhibitory potential of Saussurea costus and Saussurea involucrata phytoconstituents against the Spike glycoprotein receptor binding domain of SARS-CoV-2 Delta (B.1.617.2) variant and the main protease (M(pro)) as therapeutic candidates, using Molecular docking, DFT, and ADME/Tox studies
por: Houchi, Selma, et al.
Publicado: (2022)

Tragia Cannabina & Involucrata
por: Mootoosawmy, P. S.
Publicado: (1889)

Investigation of the Mechanism of Periploca forrestii against Rheumatoid Arthritis with Network Pharmacology-Based Analysis
por: Wang, Qiuyi, et al.
Publicado: (2022)

Integrating Network Pharmacology with Molecular Docking to Unravel the Active Compounds and Potential Mechanism of Simiao Pill Treating Rheumatoid Arthritis
por: Tang, Mengshi, et al.
Publicado: (2020)

Lactiplantibacillus plantarum and Saussurea costus as Therapeutic Agents against a Diabetic Rat Model—Approaches to Investigate Pharmacophore Modeling of Human IkB Kinase and Molecular Interaction with Dehydrocostus Lactone of Saussurea costus
por: AlGeffari, Metab A., et al.
Publicado: (2023)

Acacetin from Traditionally Used Saussurea involucrata Kar. et Kir. Suppressed Adipogenesis in 3T3-L1 Adipocytes and Attenuated Lipid Accumulation in Obese Mice
por: Liou, Chian-Jiun, et al.
Publicado: (2017)

SiFBA5, a cold-responsive factor from Saussurea involucrata promotes cold resilience and biomass increase in transgenic tomato plants under cold stress
por: Mu, Jianqiang, et al.
Publicado: (2021)

A Preliminary Note on the Pharmacological Action and Therapeutic Properties of Kuth Root—Saussurea Lappa
por: Chopra, R. N., et al.
Publicado: (1924)

Complete Chloroplast Genomes of Saussurea katochaete, Saussurea superba, and Saussurea stella: Genome Structures and Comparative and Phylogenetic Analyses
por: He, Hui, et al.
Publicado: (2023)

Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation
por: Aihaiti, Yirixiati, et al.
Publicado: (2021)

Network pharmacology-based pharmacological mechanism prediction on Eucommia ulmoides against rheumatoid arthritis
por: Ying, Yonggan, et al.
Publicado: (2022)

Investigation of the active ingredients and pharmacological mechanisms of Porana sinensis Hemsl. Against rheumatoid arthritis using network pharmacology and experimental validation
por: Hu, Jing, et al.
Publicado: (2022)

Network Pharmacology and Molecular Docking-Based Prediction of the Mechanism of Qianghuo Shengshi Decoction against Rheumatoid Arthritis
por: Zeng, Zhihao, et al.
Publicado: (2021)

The Abundant Phytocannabinoids in Rheumatoid Arthritis: Therapeutic Targets and Molecular Processes Identified Using Integrated Bioinformatics and Network Pharmacology
por: Nandi, Arijit, et al.
Publicado: (2023)

The complete chloroplast genome sequence of Davidia involucrata
por: Ang, Li, et al.
Publicado: (2021)

Use of Network Pharmacology to Investigate the Mechanism of the Compound Xuanju Capsule in the Treatment of Rheumatoid Arthritis
por: Wei, Wenyang, et al.
Publicado: (2021)

Deciphering the pharmacological mechanisms of Chaenomeles Fructus against rheumatoid arthritis by integrating network pharmacology and experimental validation
por: Sun, Mengjia, et al.
Publicado: (2022)

Immunomodulatory Activity of Polysaccharides Isolated from Saussurea salicifolia L. and Saussurea frolovii Ledeb
por: Schepetkin, Igor A., et al.
Publicado: (2023)

Therapeutic effects of shaogan fuzi decoction in rheumatoid arthritis: Network pharmacology and experimental validation
por: Shi, Lu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m47plqqjacv4caksb6h4ffp7j7