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The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls

Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hy...

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Autores principales: Leser, Bernadette, Dalkner, Nina, Tmava-Berisha, Adelina, Fellendorf, Frederike T., Unterrainer, Human-Friedrich, Stross, Tatjana, Maget, Alexander, Platzer, Martina, Bengesser, Susanne A., Häussl, Alfred, Zwigl, Ina, Birner, Armin, Queissner, Robert, Stix, Katharina, Wels, Linda, Schönthaler, Elena M. D., Lenger, Melanie, Schwerdtfeger, Andreas R., Zelzer, Sieglinde, Herrmann, Markus, Reininghaus, Eva Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574501/
https://www.ncbi.nlm.nih.gov/pubmed/37836395
http://dx.doi.org/10.3390/nu15194111
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author Leser, Bernadette
Dalkner, Nina
Tmava-Berisha, Adelina
Fellendorf, Frederike T.
Unterrainer, Human-Friedrich
Stross, Tatjana
Maget, Alexander
Platzer, Martina
Bengesser, Susanne A.
Häussl, Alfred
Zwigl, Ina
Birner, Armin
Queissner, Robert
Stix, Katharina
Wels, Linda
Schönthaler, Elena M. D.
Lenger, Melanie
Schwerdtfeger, Andreas R.
Zelzer, Sieglinde
Herrmann, Markus
Reininghaus, Eva Z.
author_facet Leser, Bernadette
Dalkner, Nina
Tmava-Berisha, Adelina
Fellendorf, Frederike T.
Unterrainer, Human-Friedrich
Stross, Tatjana
Maget, Alexander
Platzer, Martina
Bengesser, Susanne A.
Häussl, Alfred
Zwigl, Ina
Birner, Armin
Queissner, Robert
Stix, Katharina
Wels, Linda
Schönthaler, Elena M. D.
Lenger, Melanie
Schwerdtfeger, Andreas R.
Zelzer, Sieglinde
Herrmann, Markus
Reininghaus, Eva Z.
author_sort Leser, Bernadette
collection PubMed
description Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D), 24,25 dihydroxyvitamin D (24,25(OH)2D, the vitamin D metabolite ratio (VMR) and cognition in a cohort of euthymic patients with bipolar disorder. Vitamin D metabolites were measured simultaneously by liquid-chromatography tandem mass-spectrometry in serum samples from 86 outpatients with bipolar disorder and 93 healthy controls. Neither the inactive precursor 25(OH)D, nor the primary vitamin D catabolite 24,25(OH)2D, or the vitamin D metabolite ratio were significantly associated with the domains “attention”, “memory”, or “executive function” in individuals with bipolar disorder and healthy controls. Further, no vitamin D deficiency effect or interaction group × vitamin D deficiency was found in the cognitive domain scores. In summary, the present study does not support vitamin D metabolism as a modulating factor of cognitive function in euthymic BD patients. Considering the current study’s cross-sectional design, future research should expand these results in a longitudinal setting and include additional aspects of mental health, such as manic or depressive symptoms, long-term illness course and psychopharmacological treatment.
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spelling pubmed-105745012023-10-14 The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls Leser, Bernadette Dalkner, Nina Tmava-Berisha, Adelina Fellendorf, Frederike T. Unterrainer, Human-Friedrich Stross, Tatjana Maget, Alexander Platzer, Martina Bengesser, Susanne A. Häussl, Alfred Zwigl, Ina Birner, Armin Queissner, Robert Stix, Katharina Wels, Linda Schönthaler, Elena M. D. Lenger, Melanie Schwerdtfeger, Andreas R. Zelzer, Sieglinde Herrmann, Markus Reininghaus, Eva Z. Nutrients Article Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D), 24,25 dihydroxyvitamin D (24,25(OH)2D, the vitamin D metabolite ratio (VMR) and cognition in a cohort of euthymic patients with bipolar disorder. Vitamin D metabolites were measured simultaneously by liquid-chromatography tandem mass-spectrometry in serum samples from 86 outpatients with bipolar disorder and 93 healthy controls. Neither the inactive precursor 25(OH)D, nor the primary vitamin D catabolite 24,25(OH)2D, or the vitamin D metabolite ratio were significantly associated with the domains “attention”, “memory”, or “executive function” in individuals with bipolar disorder and healthy controls. Further, no vitamin D deficiency effect or interaction group × vitamin D deficiency was found in the cognitive domain scores. In summary, the present study does not support vitamin D metabolism as a modulating factor of cognitive function in euthymic BD patients. Considering the current study’s cross-sectional design, future research should expand these results in a longitudinal setting and include additional aspects of mental health, such as manic or depressive symptoms, long-term illness course and psychopharmacological treatment. MDPI 2023-09-22 /pmc/articles/PMC10574501/ /pubmed/37836395 http://dx.doi.org/10.3390/nu15194111 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leser, Bernadette
Dalkner, Nina
Tmava-Berisha, Adelina
Fellendorf, Frederike T.
Unterrainer, Human-Friedrich
Stross, Tatjana
Maget, Alexander
Platzer, Martina
Bengesser, Susanne A.
Häussl, Alfred
Zwigl, Ina
Birner, Armin
Queissner, Robert
Stix, Katharina
Wels, Linda
Schönthaler, Elena M. D.
Lenger, Melanie
Schwerdtfeger, Andreas R.
Zelzer, Sieglinde
Herrmann, Markus
Reininghaus, Eva Z.
The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls
title The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls
title_full The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls
title_fullStr The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls
title_full_unstemmed The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls
title_short The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls
title_sort influence of vitamin d status on cognitive ability in patients with bipolar disorder and healthy controls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574501/
https://www.ncbi.nlm.nih.gov/pubmed/37836395
http://dx.doi.org/10.3390/nu15194111
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