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Dietary Potassium and Clinical Outcomes among Patients on Peritoneal Dialysis

Background: The association between dietary potassium and clinical prognosis is unclear in patients with chronic kidney disease (CKD). Here, we explored the association between dietary potassium intake and all-cause and cardiovascular (CV) mortality in peritoneal dialysis (PD) patients. Methods: Her...

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Autores principales: Pan, Jinru, Xu, Xiao, Wang, Zi, Ma, Tiantian, Dong, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574508/
https://www.ncbi.nlm.nih.gov/pubmed/37836555
http://dx.doi.org/10.3390/nu15194271
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author Pan, Jinru
Xu, Xiao
Wang, Zi
Ma, Tiantian
Dong, Jie
author_facet Pan, Jinru
Xu, Xiao
Wang, Zi
Ma, Tiantian
Dong, Jie
author_sort Pan, Jinru
collection PubMed
description Background: The association between dietary potassium and clinical prognosis is unclear in patients with chronic kidney disease (CKD). Here, we explored the association between dietary potassium intake and all-cause and cardiovascular (CV) mortality in peritoneal dialysis (PD) patients. Methods: Here, we present a retrospective analysis of a prospective study. Patients that began incident PD in our center between 1 October 2002 and 31 August 2014 were screened. We recorded all demographic and clinical data at baseline. Repeated measurements were recorded at regular intervals to calculate time-averaged values. Spline regression analysis and Cox proportional regression models were used to evaluate the relationship between dietary potassium and mortality. Results: We followed 881 PD patients for 45.0 (21.5, 80.0) months; 467 patients died, of which 189 (40.5%) died of CV death and 93 were still on PD treatment. Compared with those who had baseline dietary potassium ≥1200 mg/d, the majority of patients with lower dietary potassium were female, older, or poorly educated. They were prone to have poorer nutritional status, CV disease, and diabetes mellitus (p < 0.05). In the unadjusted analysis, both baseline and time-averaged dietary potassium <1200 mg/d predicted higher all-cause and CV mortality (p < 0.001~0.01). After adjusting for demographic and laboratory data, the association between potassium intake and all-cause and CV mortality weakened, which even disappeared after additional adjustment for dietary fiber, protein, and energy intake. Conclusions: Dietary potassium in PD patients was not independently associated with all-cause and CV mortality.
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spelling pubmed-105745082023-10-14 Dietary Potassium and Clinical Outcomes among Patients on Peritoneal Dialysis Pan, Jinru Xu, Xiao Wang, Zi Ma, Tiantian Dong, Jie Nutrients Article Background: The association between dietary potassium and clinical prognosis is unclear in patients with chronic kidney disease (CKD). Here, we explored the association between dietary potassium intake and all-cause and cardiovascular (CV) mortality in peritoneal dialysis (PD) patients. Methods: Here, we present a retrospective analysis of a prospective study. Patients that began incident PD in our center between 1 October 2002 and 31 August 2014 were screened. We recorded all demographic and clinical data at baseline. Repeated measurements were recorded at regular intervals to calculate time-averaged values. Spline regression analysis and Cox proportional regression models were used to evaluate the relationship between dietary potassium and mortality. Results: We followed 881 PD patients for 45.0 (21.5, 80.0) months; 467 patients died, of which 189 (40.5%) died of CV death and 93 were still on PD treatment. Compared with those who had baseline dietary potassium ≥1200 mg/d, the majority of patients with lower dietary potassium were female, older, or poorly educated. They were prone to have poorer nutritional status, CV disease, and diabetes mellitus (p < 0.05). In the unadjusted analysis, both baseline and time-averaged dietary potassium <1200 mg/d predicted higher all-cause and CV mortality (p < 0.001~0.01). After adjusting for demographic and laboratory data, the association between potassium intake and all-cause and CV mortality weakened, which even disappeared after additional adjustment for dietary fiber, protein, and energy intake. Conclusions: Dietary potassium in PD patients was not independently associated with all-cause and CV mortality. MDPI 2023-10-06 /pmc/articles/PMC10574508/ /pubmed/37836555 http://dx.doi.org/10.3390/nu15194271 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pan, Jinru
Xu, Xiao
Wang, Zi
Ma, Tiantian
Dong, Jie
Dietary Potassium and Clinical Outcomes among Patients on Peritoneal Dialysis
title Dietary Potassium and Clinical Outcomes among Patients on Peritoneal Dialysis
title_full Dietary Potassium and Clinical Outcomes among Patients on Peritoneal Dialysis
title_fullStr Dietary Potassium and Clinical Outcomes among Patients on Peritoneal Dialysis
title_full_unstemmed Dietary Potassium and Clinical Outcomes among Patients on Peritoneal Dialysis
title_short Dietary Potassium and Clinical Outcomes among Patients on Peritoneal Dialysis
title_sort dietary potassium and clinical outcomes among patients on peritoneal dialysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574508/
https://www.ncbi.nlm.nih.gov/pubmed/37836555
http://dx.doi.org/10.3390/nu15194271
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