Cargando…
Ameliorating Effects of Bifidobacterium longum subsp. infantis FB3-14 against High-Fat-Diet-Induced Obesity and Gut Microbiota Disorder
Obesity has emerged as one of the most prevalent chronic diseases worldwide. Our study was conducted to investigate the anti-obese potential of novel probiotic Bifidobacterium longum subsp. infantis FB3-14 (FB3-14) and the underlying molecular mechanisms in high-fat diet (HFD)-fed mice. The results...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574542/ https://www.ncbi.nlm.nih.gov/pubmed/37836387 http://dx.doi.org/10.3390/nu15194104 |
_version_ | 1785120717046546432 |
---|---|
author | Kou, Ruixin Wang, Jin Li, Ang Wang, Yuanyifei Zhang, Bowei Liu, Jingmin Sun, Yi Wang, Shuo |
author_facet | Kou, Ruixin Wang, Jin Li, Ang Wang, Yuanyifei Zhang, Bowei Liu, Jingmin Sun, Yi Wang, Shuo |
author_sort | Kou, Ruixin |
collection | PubMed |
description | Obesity has emerged as one of the most prevalent chronic diseases worldwide. Our study was conducted to investigate the anti-obese potential of novel probiotic Bifidobacterium longum subsp. infantis FB3-14 (FB3-14) and the underlying molecular mechanisms in high-fat diet (HFD)-fed mice. The results demonstrated that an 8-week FB3-14 intervention significantly suppressed the HFD-induced body and fat weight gain and abnormal alterations of the serum lipid parameter, restoring the levels of cholesterol (4.29 mmol/L) and low-density lipoprotein cholesterol (3.42 mmol/L). FB3-14 treatment also attenuated adipocyte expansion, hepatic injury, and low-grade systemic inflammation and restored the expressions of lipid-metabolism-related genes, including Hsl, Leptin, and Adiponectin. Furthermore, FB3-14 was observed to reduce the Firmicutes/Bacteroidetes ratio in obese mice; increase the abundance of Akkermansia muciniphila, unclassified_Muribaculaceae, Lachnospiraceae_NK4A136_group, and Bifidobacterim; and upregulate G protein-coupled receptor41 associated with higher levels of butyric acid. These results indicate the protective effectiveness of FB3-14 in HFD-driven obesity and gut microbiota disorders, highlighting the promising potential of FB3-14 as a functional nutrition supplement. |
format | Online Article Text |
id | pubmed-10574542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105745422023-10-14 Ameliorating Effects of Bifidobacterium longum subsp. infantis FB3-14 against High-Fat-Diet-Induced Obesity and Gut Microbiota Disorder Kou, Ruixin Wang, Jin Li, Ang Wang, Yuanyifei Zhang, Bowei Liu, Jingmin Sun, Yi Wang, Shuo Nutrients Article Obesity has emerged as one of the most prevalent chronic diseases worldwide. Our study was conducted to investigate the anti-obese potential of novel probiotic Bifidobacterium longum subsp. infantis FB3-14 (FB3-14) and the underlying molecular mechanisms in high-fat diet (HFD)-fed mice. The results demonstrated that an 8-week FB3-14 intervention significantly suppressed the HFD-induced body and fat weight gain and abnormal alterations of the serum lipid parameter, restoring the levels of cholesterol (4.29 mmol/L) and low-density lipoprotein cholesterol (3.42 mmol/L). FB3-14 treatment also attenuated adipocyte expansion, hepatic injury, and low-grade systemic inflammation and restored the expressions of lipid-metabolism-related genes, including Hsl, Leptin, and Adiponectin. Furthermore, FB3-14 was observed to reduce the Firmicutes/Bacteroidetes ratio in obese mice; increase the abundance of Akkermansia muciniphila, unclassified_Muribaculaceae, Lachnospiraceae_NK4A136_group, and Bifidobacterim; and upregulate G protein-coupled receptor41 associated with higher levels of butyric acid. These results indicate the protective effectiveness of FB3-14 in HFD-driven obesity and gut microbiota disorders, highlighting the promising potential of FB3-14 as a functional nutrition supplement. MDPI 2023-09-22 /pmc/articles/PMC10574542/ /pubmed/37836387 http://dx.doi.org/10.3390/nu15194104 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kou, Ruixin Wang, Jin Li, Ang Wang, Yuanyifei Zhang, Bowei Liu, Jingmin Sun, Yi Wang, Shuo Ameliorating Effects of Bifidobacterium longum subsp. infantis FB3-14 against High-Fat-Diet-Induced Obesity and Gut Microbiota Disorder |
title | Ameliorating Effects of Bifidobacterium longum subsp. infantis FB3-14 against High-Fat-Diet-Induced Obesity and Gut Microbiota Disorder |
title_full | Ameliorating Effects of Bifidobacterium longum subsp. infantis FB3-14 against High-Fat-Diet-Induced Obesity and Gut Microbiota Disorder |
title_fullStr | Ameliorating Effects of Bifidobacterium longum subsp. infantis FB3-14 against High-Fat-Diet-Induced Obesity and Gut Microbiota Disorder |
title_full_unstemmed | Ameliorating Effects of Bifidobacterium longum subsp. infantis FB3-14 against High-Fat-Diet-Induced Obesity and Gut Microbiota Disorder |
title_short | Ameliorating Effects of Bifidobacterium longum subsp. infantis FB3-14 against High-Fat-Diet-Induced Obesity and Gut Microbiota Disorder |
title_sort | ameliorating effects of bifidobacterium longum subsp. infantis fb3-14 against high-fat-diet-induced obesity and gut microbiota disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574542/ https://www.ncbi.nlm.nih.gov/pubmed/37836387 http://dx.doi.org/10.3390/nu15194104 |
work_keys_str_mv | AT kouruixin amelioratingeffectsofbifidobacteriumlongumsubspinfantisfb314againsthighfatdietinducedobesityandgutmicrobiotadisorder AT wangjin amelioratingeffectsofbifidobacteriumlongumsubspinfantisfb314againsthighfatdietinducedobesityandgutmicrobiotadisorder AT liang amelioratingeffectsofbifidobacteriumlongumsubspinfantisfb314againsthighfatdietinducedobesityandgutmicrobiotadisorder AT wangyuanyifei amelioratingeffectsofbifidobacteriumlongumsubspinfantisfb314againsthighfatdietinducedobesityandgutmicrobiotadisorder AT zhangbowei amelioratingeffectsofbifidobacteriumlongumsubspinfantisfb314againsthighfatdietinducedobesityandgutmicrobiotadisorder AT liujingmin amelioratingeffectsofbifidobacteriumlongumsubspinfantisfb314againsthighfatdietinducedobesityandgutmicrobiotadisorder AT sunyi amelioratingeffectsofbifidobacteriumlongumsubspinfantisfb314againsthighfatdietinducedobesityandgutmicrobiotadisorder AT wangshuo amelioratingeffectsofbifidobacteriumlongumsubspinfantisfb314againsthighfatdietinducedobesityandgutmicrobiotadisorder |