The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity

Agelastatin A is a marine alkaloid with potent biological activity. To date, at least 17 different strategies have achieved its total synthesis, along with many analogues. The present study focuses on the acidity stability of some N-methyl derivatives of agelastatin A. The study made use of chemical...

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Detalles Bibliográficos
Autor principal: D’Ambrosio, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574546/
https://www.ncbi.nlm.nih.gov/pubmed/37836663
http://dx.doi.org/10.3390/molecules28196821
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author D’Ambrosio, Michele
author_facet D’Ambrosio, Michele
author_sort D’Ambrosio, Michele
collection PubMed
description Agelastatin A is a marine alkaloid with potent biological activity. To date, at least 17 different strategies have achieved its total synthesis, along with many analogues. The present study focuses on the acidity stability of some N-methyl derivatives of agelastatin A. The study made use of chemical reactions and spectroscopic acquisitions. The chemical structure of some derivatives can undergo a profound rearrangement. The results could shed light on the mechanism of action of agelastatin A and suggest the preparation of analogues with improved pharmacological efficacy.
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spelling pubmed-105745462023-10-14 The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity D’Ambrosio, Michele Molecules Article Agelastatin A is a marine alkaloid with potent biological activity. To date, at least 17 different strategies have achieved its total synthesis, along with many analogues. The present study focuses on the acidity stability of some N-methyl derivatives of agelastatin A. The study made use of chemical reactions and spectroscopic acquisitions. The chemical structure of some derivatives can undergo a profound rearrangement. The results could shed light on the mechanism of action of agelastatin A and suggest the preparation of analogues with improved pharmacological efficacy. MDPI 2023-09-27 /pmc/articles/PMC10574546/ /pubmed/37836663 http://dx.doi.org/10.3390/molecules28196821 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
D’Ambrosio, Michele
The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity
title The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity
title_full The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity
title_fullStr The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity
title_full_unstemmed The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity
title_short The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity
title_sort n-alkylation of agelastatin a modulates its chemical reactivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574546/
https://www.ncbi.nlm.nih.gov/pubmed/37836663
http://dx.doi.org/10.3390/molecules28196821
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