Cargando…

Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism

In recent years, ketogenic diets and ketone supplements have increased in popularity, particularly as a mechanism to improve exercise performance by modifying energetics. Since the skeletal muscle is a major metabolic and locomotory organ, it is important to take it into consideration when consideri...

Descripción completa

Detalles Bibliográficos
Autores principales: Khouri, Hannah, Ussher, John R., Aguer, Céline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574738/
https://www.ncbi.nlm.nih.gov/pubmed/37836512
http://dx.doi.org/10.3390/nu15194228
_version_ 1785120762493927424
author Khouri, Hannah
Ussher, John R.
Aguer, Céline
author_facet Khouri, Hannah
Ussher, John R.
Aguer, Céline
author_sort Khouri, Hannah
collection PubMed
description In recent years, ketogenic diets and ketone supplements have increased in popularity, particularly as a mechanism to improve exercise performance by modifying energetics. Since the skeletal muscle is a major metabolic and locomotory organ, it is important to take it into consideration when considering the effect of a dietary intervention, and the impact of physical activity on the body. The goal of this review is to summarize what is currently known and what still needs to be investigated concerning the relationship between ketone body metabolism and exercise, specifically in the skeletal muscle. Overall, it is clear that increased exposure to ketone bodies in combination with exercise can modify skeletal muscle metabolism, but whether this effect is beneficial or detrimental remains unclear and needs to be further interrogated before ketogenic diets or exogenous ketone supplementation can be recommended.
format Online
Article
Text
id pubmed-10574738
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105747382023-10-14 Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism Khouri, Hannah Ussher, John R. Aguer, Céline Nutrients Review In recent years, ketogenic diets and ketone supplements have increased in popularity, particularly as a mechanism to improve exercise performance by modifying energetics. Since the skeletal muscle is a major metabolic and locomotory organ, it is important to take it into consideration when considering the effect of a dietary intervention, and the impact of physical activity on the body. The goal of this review is to summarize what is currently known and what still needs to be investigated concerning the relationship between ketone body metabolism and exercise, specifically in the skeletal muscle. Overall, it is clear that increased exposure to ketone bodies in combination with exercise can modify skeletal muscle metabolism, but whether this effect is beneficial or detrimental remains unclear and needs to be further interrogated before ketogenic diets or exogenous ketone supplementation can be recommended. MDPI 2023-09-30 /pmc/articles/PMC10574738/ /pubmed/37836512 http://dx.doi.org/10.3390/nu15194228 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khouri, Hannah
Ussher, John R.
Aguer, Céline
Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism
title Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism
title_full Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism
title_fullStr Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism
title_full_unstemmed Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism
title_short Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism
title_sort exogenous ketone supplementation and ketogenic diets for exercise: considering the effect on skeletal muscle metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574738/
https://www.ncbi.nlm.nih.gov/pubmed/37836512
http://dx.doi.org/10.3390/nu15194228
work_keys_str_mv AT khourihannah exogenousketonesupplementationandketogenicdietsforexerciseconsideringtheeffectonskeletalmusclemetabolism
AT ussherjohnr exogenousketonesupplementationandketogenicdietsforexerciseconsideringtheeffectonskeletalmusclemetabolism
AT aguerceline exogenousketonesupplementationandketogenicdietsforexerciseconsideringtheeffectonskeletalmusclemetabolism