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In Vitro Enzyme Kinetics and NMR-Based Product Elucidation for Glutathione S-Conjugation of the Anticancer Unsymmetrical Bisacridine C-2028 in Liver Microsomes and Cytosol: Major Role of Glutathione S-Transferase M1-1 Isoenzyme

This work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-dependent GSH conjugation of C-2028 in rat liver micros...

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Detalles Bibliográficos
Autores principales: Potęga, Agnieszka, Rafalska, Dominika, Kazimierczyk, Dawid, Kosno, Michał, Pawłowicz, Aleksandra, Andrałojć, Witold, Paluszkiewicz, Ewa, Laskowski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574777/
https://www.ncbi.nlm.nih.gov/pubmed/37836655
http://dx.doi.org/10.3390/molecules28196812