The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors

Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) were previously shown to have selective positive modulation at the metabotropic glutamate receptor (mGluR) Subtypes 2 and 4, with no functional cross-reactivity at mGluR(1a), mGluR(5), or mGluR(8). Additional analogs were prepared to access more of the allos...

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Detalles Bibliográficos
Autores principales: Gates, Christina A., Backos, Donald S., Reigan, Philip, Natale, Nicholas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574779/
https://www.ncbi.nlm.nih.gov/pubmed/37836643
http://dx.doi.org/10.3390/molecules28196800

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