Effect of Tryptic Digestion on Sensitivity and Specificity in MALDI-TOF-Based Molecular Diagnostics through Machine Learning

The digestion of protein into peptide fragments reduces the size and complexity of protein molecules. Peptide fragments can be analyzed with higher sensitivity (often > 10(2) fold) and resolution using MALDI-TOF mass spectrometers, leading to improved pattern recognition by common machine learnin...

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Detalles Bibliográficos
Autores principales: Sarkar, Sumon, Squire, Abigail, Diab, Hanin, Rahman, Md. Kaisar, Perdomo, Angela, Awosile, Babafela, Calle, Alexandra, Thompson, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575185/
https://www.ncbi.nlm.nih.gov/pubmed/37836873
http://dx.doi.org/10.3390/s23198042

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