Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses

Alongshan virus (ALSV), a newly discovered member of unclassified Flaviviridae family, is able to infect humans. ALSV has a multi-segmented genome organization and is evolutionarily distant from canonical mono-segmented flaviviruses. The virus-encoded methyltransferase (MTase) plays an important rol...

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Detalles Bibliográficos
Autores principales: Chen, Hua, Lin, Sheng, Yang, Fanli, Chen, Zimin, Guo, Liyan, Yang, Jing, Lin, Xi, Wang, Lingling, Duan, Yanping, Wen, Ao, Zhang, Xindan, Dai, Yushan, Yin, Keqing, Yuan, Xin, Yu, Chongzhang, He, Yarong, He, Bin, Cao, Yu, Dong, Haohao, Li, Jian, Zhao, Qi, Liu, Quan, Lu, Guangwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575543/
https://www.ncbi.nlm.nih.gov/pubmed/37831643
http://dx.doi.org/10.1371/journal.ppat.1011694

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