Thrombospondin-1 proteomimetic polymers exhibit anti-angiogenic activity in a neovascular age-related macular degeneration mouse model

Neovascular age-related macular degeneration (nAMD) is the leading cause of blindness in the developed world. Current therapy includes monthly intraocular injections of anti-VEGF antibodies, which are ineffective in up to one third of patients. Thrombospondin-1 (TSP1) inhibits angiogenesis via CD36...

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Detalles Bibliográficos
Autores principales: Choi, Wonmin, Nensel, Ashley K., Droho, Steven, Fattah, Mara A., Mokashi-Punekar, Soumitra, Swygart, David I., Burton, Spencer T., Schwartz, Greg W., Lavine, Jeremy A., Gianneschi, Nathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575579/
https://www.ncbi.nlm.nih.gov/pubmed/37831763
http://dx.doi.org/10.1126/sciadv.adi8534

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