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Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain binding

Heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1L) serves as a unique E3 ligase to catalyze the mono-ubiquitination of relevant protein or sugar substrates and plays vital roles in numerous cellular processes in mammals. However, the molecular mechanism underpinning the E3 activity of HOIL-1L and the r...

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Detalles Bibliográficos
Autores principales:	Xu, Xiaolong, Wang, Yaru, Zhang, Yan, Wang, Yingli, Yin, Yue, Peng, Chao, Gong, Xinyu, Li, Miao, Zhang, Yuchao, Zhang, Mingfang, Tang, Yubin, Zhou, Xindi, Liu, Haobo, Pan, Lifeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575588/ https://www.ncbi.nlm.nih.gov/pubmed/37831767 http://dx.doi.org/10.1126/sciadv.adi4599

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