Molecular basis of ClC-6 function and its impairment in human disease

ClC-6 is a late endosomal voltage-gated chloride-proton exchanger that is predominantly expressed in the nervous system. Mutated forms of ClC-6 are associated with severe neurological disease. However, the mechanistic role of ClC-6 in normal and pathological states remains largely unknown. Here, we...

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Detalles Bibliográficos
Autores principales: Zhang, Bing, Zhang, Sensen, Polovitskaya, Maya M., Yi, Jingbo, Ye, Binglu, Li, Ruochong, Huang, Xueying, Yin, Jian, Neuens, Sebastian, Balfroid, Tom, Soblet, Julie, Vens, Daphné, Aeby, Alec, Li, Xiaoling, Cai, Jinjin, Song, Yingcai, Li, Yuanxi, Tartaglia, Marco, Li, Yang, Jentsch, Thomas J., Yang, Maojun, Liu, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575590/
https://www.ncbi.nlm.nih.gov/pubmed/37831762
http://dx.doi.org/10.1126/sciadv.adg4479

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