Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer

Inherent or acquired resistance to sotorasib poses a substantialt challenge for NSCLC treatment. Here, we demonstrate that acquired resistance to sotorasib in isogenic cells correlated with increased expression of integrin β4 (ITGB4), a component of the focal adhesion complex. Silencing ITGB4 in tol...

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Detalles Bibliográficos
Autores principales: Mohanty, Atish, Nam, Arin, Srivastava, Saumya, Jones, Jeff, Lomenick, Brett, Singhal, Sharad S., Guo, Linlin, Cho, Hyejin, Li, Aimin, Behal, Amita, Mirzapoiazova, Tamara, Massarelli, Erminia, Koczywas, Marianna, Arvanitis, Leonidas D., Walser, Tonya, Villaflor, Victoria, Hamilton, Stanley, Mambetsariev, Isa, Sattler, Martin, Nasser, Mohd W., Jain, Maneesh, Batra, Surinder K., Soldi, Raffaella, Sharma, Sunil, Fakih, Marwan, Mohanty, Saswat Kumar, Mainan, Avijit, Wu, Xiwei, Chen, Yihong, He, Yanan, Chou, Tsui-Fen, Roy, Susmita, Orban, John, Kulkarni, Prakash, Salgia, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575592/
https://www.ncbi.nlm.nih.gov/pubmed/37831779
http://dx.doi.org/10.1126/sciadv.ade3816

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