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Puzzle resolved: CFTR mediates chloride homeostasis by segregating absorption and secretion to different cell types

In the lungs, the cystic fibrosis transmembrane conductance regulator (CFTR) regulates ion transport in surface-airway epithelia and submucosal glands, thus determining airway surface liquid (ASL) volume and mucus hydration. In this issue of the JCI, Lei Lei and colleagues report that the CFTR-rich...

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Autor principal: Tümmler, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575718/
https://www.ncbi.nlm.nih.gov/pubmed/37843282
http://dx.doi.org/10.1172/JCI174667
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author Tümmler, Burkhard
author_facet Tümmler, Burkhard
author_sort Tümmler, Burkhard
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description In the lungs, the cystic fibrosis transmembrane conductance regulator (CFTR) regulates ion transport in surface-airway epithelia and submucosal glands, thus determining airway surface liquid (ASL) volume and mucus hydration. In this issue of the JCI, Lei Lei and colleagues report that the CFTR-rich and barttin/Cl(–) channel–expressing ionocytes mediate chloride absorption across airway epithelia, whereas the more abundant basal cells and secretory cells mediate chloride secretion. Thus, CFTR-mediated secretion and absorption of chloride ions in the lung are segregated by cell type, which has implications for future molecular therapies for cystic fibrosis lung disease.
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spelling pubmed-105757182023-10-16 Puzzle resolved: CFTR mediates chloride homeostasis by segregating absorption and secretion to different cell types Tümmler, Burkhard J Clin Invest Commentary In the lungs, the cystic fibrosis transmembrane conductance regulator (CFTR) regulates ion transport in surface-airway epithelia and submucosal glands, thus determining airway surface liquid (ASL) volume and mucus hydration. In this issue of the JCI, Lei Lei and colleagues report that the CFTR-rich and barttin/Cl(–) channel–expressing ionocytes mediate chloride absorption across airway epithelia, whereas the more abundant basal cells and secretory cells mediate chloride secretion. Thus, CFTR-mediated secretion and absorption of chloride ions in the lung are segregated by cell type, which has implications for future molecular therapies for cystic fibrosis lung disease. American Society for Clinical Investigation 2023-10-16 /pmc/articles/PMC10575718/ /pubmed/37843282 http://dx.doi.org/10.1172/JCI174667 Text en © 2023 Tümmler et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Tümmler, Burkhard
Puzzle resolved: CFTR mediates chloride homeostasis by segregating absorption and secretion to different cell types
title Puzzle resolved: CFTR mediates chloride homeostasis by segregating absorption and secretion to different cell types
title_full Puzzle resolved: CFTR mediates chloride homeostasis by segregating absorption and secretion to different cell types
title_fullStr Puzzle resolved: CFTR mediates chloride homeostasis by segregating absorption and secretion to different cell types
title_full_unstemmed Puzzle resolved: CFTR mediates chloride homeostasis by segregating absorption and secretion to different cell types
title_short Puzzle resolved: CFTR mediates chloride homeostasis by segregating absorption and secretion to different cell types
title_sort puzzle resolved: cftr mediates chloride homeostasis by segregating absorption and secretion to different cell types
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575718/
https://www.ncbi.nlm.nih.gov/pubmed/37843282
http://dx.doi.org/10.1172/JCI174667
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