Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation

The NOD-, LRR-, and pyrin domain–containing protein 3 (NLRP3) inflammasome is a crucial component of the innate immune system that initiates inflammatory responses. Posttranslational modifications (PTMs) of NLRP3, including ubiquitination and phosphorylation, control inflammasome activation and dete...

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Detalles Bibliográficos
Autores principales: Qin, Ying, Meng, Xintong, Wang, Mengge, Liang, Wenbo, Xu, Rong, Chen, Jingchunyu, Song, Hui, Fu, Yue, Li, Jingxin, Gao, Chengjiang, Jia, Mutian, Zhao, Chunyuan, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575725/
https://www.ncbi.nlm.nih.gov/pubmed/37651190
http://dx.doi.org/10.1172/JCI161935

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