Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation

Regulatory T cells (Tregs) are instrumental in maintaining immune tolerance and preventing destructive autoimmunity, but how heterogeneous Treg populations are established remains largely unknown. Here, we show that Zfp335 deletion in Tregs failed to differentiate into effector Tregs (eTregs) and lo...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Sun, Lina, Yang, Biao, Li, Wenhua, Zhang, Cangang, Yang, Xiaofeng, Sun, Yae, Shen, Xiaonan, Gao, Yang, Ju, Bomiao, Gao, Yafeng, Liu, Dan, Song, Jiapeng, Jia, Xiaoxuan, Su, Yanhong, Jiao, Anjun, Liu, Haiyan, Zhang, Lianjun, Lan He, Lei, Lei, Chen, WanJun, Zhang, Baojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575732/
https://www.ncbi.nlm.nih.gov/pubmed/37843279
http://dx.doi.org/10.1172/JCI166628

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