Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src

Endothelial phospholipase Cγ (PLCγ) is essential for vascular development; however, its role in healthy, mature, or pathological vessels is unexplored. Here, we show that PLCγ was prominently expressed in vessels of several human cancer forms, notably in renal cell carcinoma (RCC). High PLCγ express...

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Detalles Bibliográficos
Autores principales: Sjöberg, Elin, Melssen, Marit, Richards, Mark, Ding, Yindi, Chanoca, Catarina, Chen, Dongying, Nwadozi, Emmanuel, Pal, Sagnik, Love, Dominic T., Ninchoji, Takeshi, Shibuya, Masabumi, Simons, Michael, Dimberg, Anna, Claesson-Welsh, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575733/
https://www.ncbi.nlm.nih.gov/pubmed/37651195
http://dx.doi.org/10.1172/JCI161366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575733/
https://www.ncbi.nlm.nih.gov/pubmed/37651195
http://dx.doi.org/10.1172/JCI161366

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