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Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src
Endothelial phospholipase Cγ (PLCγ) is essential for vascular development; however, its role in healthy, mature, or pathological vessels is unexplored. Here, we show that PLCγ was prominently expressed in vessels of several human cancer forms, notably in renal cell carcinoma (RCC). High PLCγ express...
Autores principales: | Sjöberg, Elin, Melssen, Marit, Richards, Mark, Ding, Yindi, Chanoca, Catarina, Chen, Dongying, Nwadozi, Emmanuel, Pal, Sagnik, Love, Dominic T., Ninchoji, Takeshi, Shibuya, Masabumi, Simons, Michael, Dimberg, Anna, Claesson-Welsh, Lena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575733/ https://www.ncbi.nlm.nih.gov/pubmed/37651195 http://dx.doi.org/10.1172/JCI161366 |
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