Peroxisome disruption alters lipid metabolism and potentiates antitumor response with MAPK-targeted therapy in melanoma

Melanomas reprogram their metabolism to rapidly adapt to therapy-induced stress conditions, allowing them to persist and ultimately develop resistance. We report that a subpopulation of melanoma cells tolerate MAPK pathway inhibitors (MAPKis) through a concerted metabolic reprogramming mediated by p...

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Detalles Bibliográficos
Autores principales: Huang, Fan, Cai, Feiyang, Dahabieh, Michael S., Gunawardena, Kshemaka, Talebi, Ali, Dehairs, Jonas, El-Turk, Farah, Park, Jae Yeon, Li, Mengqi, Goncalves, Christophe, Gagnon, Natascha, Su, Jie, LaPierre, Judith H., Gaub, Perrine, Joyal, Jean-Sébastien, Mitchell, John J., Swinnen, Johannes V., Miller, Wilson H., del Rincón, Sonia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575734/
https://www.ncbi.nlm.nih.gov/pubmed/37616051
http://dx.doi.org/10.1172/JCI166644

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