SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling

The loss of contact inhibition is a key step during carcinogenesis. The Hippo–Yes-associated protein (Hippo/YAP) pathway is an important regulator of cell growth in a cell density–dependent manner. However, how Hippo signaling senses cell density in this context remains elusive. Here, we report that...

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Detalles Bibliográficos
Autores principales: Su, Dongxue, Li, Yuxi, Zhang, Weiji, Gao, Huan, Cheng, Yao, Hou, Yongqiang, Li, Junhong, Ye, Yi, Lai, Zhangjian, Li, Zhe, Huang, Haitao, Li, Jiaxin, Li, Jinhuan, Cheng, Mengyu, Nian, Cheng, Wu, Na, Zhou, Zhien, Xing, Yunzhi, Zhao, Yu, Liu, He, Tang, Jiayu, Chen, Qinghua, Hong, Lixin, Li, Wengang, Peng, Zhihai, Zhao, Bin, Johnson, Randy L., Liu, Pingguo, Hong, Wanjin, Chen, Lanfen, Zhou, Dawang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575737/
https://www.ncbi.nlm.nih.gov/pubmed/37843276
http://dx.doi.org/10.1172/JCI168888

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