AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study

Introduction: In this study, we demonstrate the feasibility of yeast surface display (YSD) and nextgeneration sequencing (NGS) in combination with artificial intelligence and machine learning methods (AI/ML) for the identification of de novo humanized single domain antibodies (sdAbs) with favorable...

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Detalles Bibliográficos
Autores principales: Arras, Paul, Yoo, Han Byul, Pekar, Lukas, Clarke, Thomas, Friedrich, Lukas, Schröter, Christian, Schanz, Jennifer, Tonillo, Jason, Siegmund, Vanessa, Doerner, Achim, Krah, Simon, Guarnera, Enrico, Zielonka, Stefan, Evers, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575757/
https://www.ncbi.nlm.nih.gov/pubmed/37842638
http://dx.doi.org/10.3389/fmolb.2023.1249247

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