Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?

Behavioural supersensitivity may be a result of increased glutamate sensitivity of D2-MSN and reduced sensitivity to dopamine. We propose that clozapine may address behavioural supersensitivity by modulating glutamate activity which may partially explain its unique effectiveness in the setting of tr...

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Autores principales: Tibrewal, Prashant, Nair, Pramod C., Gregory, Karen J., Langmead, Christopher J., Chan, Sherry Kit Wa, Bastiampillai, Tarun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575773/
https://www.ncbi.nlm.nih.gov/pubmed/36932159
http://dx.doi.org/10.1038/s41380-023-02026-x
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author Tibrewal, Prashant
Nair, Pramod C.
Gregory, Karen J.
Langmead, Christopher J.
Chan, Sherry Kit Wa
Bastiampillai, Tarun
author_facet Tibrewal, Prashant
Nair, Pramod C.
Gregory, Karen J.
Langmead, Christopher J.
Chan, Sherry Kit Wa
Bastiampillai, Tarun
author_sort Tibrewal, Prashant
collection PubMed
description Behavioural supersensitivity may be a result of increased glutamate sensitivity of D2-MSN and reduced sensitivity to dopamine. We propose that clozapine may address behavioural supersensitivity by modulating glutamate activity which may partially explain its unique effectiveness in the setting of treatment resistant schizophrenia.
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spelling pubmed-105757732023-10-15 Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum? Tibrewal, Prashant Nair, Pramod C. Gregory, Karen J. Langmead, Christopher J. Chan, Sherry Kit Wa Bastiampillai, Tarun Mol Psychiatry Comment Behavioural supersensitivity may be a result of increased glutamate sensitivity of D2-MSN and reduced sensitivity to dopamine. We propose that clozapine may address behavioural supersensitivity by modulating glutamate activity which may partially explain its unique effectiveness in the setting of treatment resistant schizophrenia. Nature Publishing Group UK 2023-03-17 2023 /pmc/articles/PMC10575773/ /pubmed/36932159 http://dx.doi.org/10.1038/s41380-023-02026-x Text en © Crown 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Tibrewal, Prashant
Nair, Pramod C.
Gregory, Karen J.
Langmead, Christopher J.
Chan, Sherry Kit Wa
Bastiampillai, Tarun
Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
title Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
title_full Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
title_fullStr Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
title_full_unstemmed Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
title_short Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
title_sort does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575773/
https://www.ncbi.nlm.nih.gov/pubmed/36932159
http://dx.doi.org/10.1038/s41380-023-02026-x
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