Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?

Behavioural supersensitivity may be a result of increased glutamate sensitivity of D2-MSN and reduced sensitivity to dopamine. We propose that clozapine may address behavioural supersensitivity by modulating glutamate activity which may partially explain its unique effectiveness in the setting of tr...

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Detalles Bibliográficos
Autores principales: Tibrewal, Prashant, Nair, Pramod C., Gregory, Karen J., Langmead, Christopher J., Chan, Sherry Kit Wa, Bastiampillai, Tarun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575773/
https://www.ncbi.nlm.nih.gov/pubmed/36932159
http://dx.doi.org/10.1038/s41380-023-02026-x

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