MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention

MYT1L is an autism spectrum disorder (ASD)-associated transcription factor that is expressed in virtually all neurons throughout life. How MYT1L mutations cause neurological phenotypes and whether they can be targeted remains enigmatic. Here, we examine the effects of MYT1L deficiency in human neuro...

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Detalles Bibliográficos
Autores principales: Weigel, Bettina, Tegethoff, Jana F., Grieder, Sarah D., Lim, Bryce, Nagarajan, Bhuvaneswari, Liu, Yu-Chao, Truberg, Jule, Papageorgiou, Dimitris, Adrian-Segarra, Juan M., Schmidt, Laura K., Kaspar, Janina, Poisel, Eric, Heinzelmann, Elisa, Saraswat, Manu, Christ, Marleen, Arnold, Christian, Ibarra, Ignacio L., Campos, Joaquin, Krijgsveld, Jeroen, Monyer, Hannah, Zaugg, Judith B., Acuna, Claudio, Mall, Moritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575775/
https://www.ncbi.nlm.nih.gov/pubmed/36782060
http://dx.doi.org/10.1038/s41380-023-01959-7

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