Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain

Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the bloodstream to the brain. However, unlike in rodents, few neurotropic AAVs efficiently cross the blood–brain barrier in...

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Detalles Bibliográficos
Autores principales: Chuapoco, Miguel R., Flytzanis, Nicholas C., Goeden, Nick, Christopher Octeau, J., Roxas, Kristina M., Chan, Ken Y., Scherrer, Jon, Winchester, Janet, Blackburn, Roy J., Campos, Lillian J., Man, Kwun Nok Mimi, Sun, Junqing, Chen, Xinhong, Lefevre, Arthur, Singh, Vikram Pal, Arokiaraj, Cynthia M., Shay, Timothy F., Vendemiatti, Julia, Jang, Min J., Mich, John K., Bishaw, Yemeserach, Gore, Bryan B., Omstead, Victoria, Taskin, Naz, Weed, Natalie, Levi, Boaz P., Ting, Jonathan T., Miller, Cory T., Deverman, Benjamin E., Pickel, James, Tian, Lin, Fox, Andrew S., Gradinaru, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575780/
https://www.ncbi.nlm.nih.gov/pubmed/37430038
http://dx.doi.org/10.1038/s41565-023-01419-x

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