Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts

The paper presents a new model of secondary injuries after traumatic brain injury. The model is based on the cultivation of rat embryonic fibroblasts reprogrammed to a neuronal phenotype in the presence of cerebrospinal fluid from injured rats. The presented model was used to test the therapeutic ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Rykunova, E. B., Mikeladze, M. A., Utepova, I. A., Chupakhin, O. N., Guzhova, I. V., Lazarev, V. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2023
Materias:
Biochemistry, Biophysics, and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575796/
https://www.ncbi.nlm.nih.gov/pubmed/37833611
http://dx.doi.org/10.1134/S1607672923700345
_version_ 1785120987199569920
author Rykunova, E. B.
Mikeladze, M. A.
Utepova, I. A.
Chupakhin, O. N.
Guzhova, I. V.
Lazarev, V. F.
author_facet Rykunova, E. B.
Mikeladze, M. A.
Utepova, I. A.
Chupakhin, O. N.
Guzhova, I. V.
Lazarev, V. F.
author_sort Rykunova, E. B.
collection PubMed
description The paper presents a new model of secondary injuries after traumatic brain injury. The model is based on the cultivation of rat embryonic fibroblasts reprogrammed to a neuronal phenotype in the presence of cerebrospinal fluid from injured rats. The presented model was used to test the therapeutic effect of inducers of the synthesis of chaperones from the classes of pyrrolylazines and indolylazines, which have neuroprotective properties.
format Online
Article
Text
id pubmed-10575796
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Pleiades Publishing
record_format MEDLINE/PubMed
spelling pubmed-105757962023-10-15 Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts Rykunova, E. B. Mikeladze, M. A. Utepova, I. A. Chupakhin, O. N. Guzhova, I. V. Lazarev, V. F. Dokl Biochem Biophys Biochemistry, Biophysics, and Molecular Biology The paper presents a new model of secondary injuries after traumatic brain injury. The model is based on the cultivation of rat embryonic fibroblasts reprogrammed to a neuronal phenotype in the presence of cerebrospinal fluid from injured rats. The presented model was used to test the therapeutic effect of inducers of the synthesis of chaperones from the classes of pyrrolylazines and indolylazines, which have neuroprotective properties. Pleiades Publishing 2023-10-13 2023 /pmc/articles/PMC10575796/ /pubmed/37833611 http://dx.doi.org/10.1134/S1607672923700345 Text en © The Author(s) 2023, ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2023, Vol. 511, pp. 235–239. © The Author(s), 2023. This article is an open access publication.Russian Text © The Author(s), 2023, published in Doklady Rossiiskoi Akademii Nauk. Nauki o Zhizni, 2023, Vol. 511, pp. 399–404. https://creativecommons.org/licenses/by/4.0/Open Access.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biochemistry, Biophysics, and Molecular Biology
Rykunova, E. B.
Mikeladze, M. A.
Utepova, I. A.
Chupakhin, O. N.
Guzhova, I. V.
Lazarev, V. F.
Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
title Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
title_full Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
title_fullStr Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
title_full_unstemmed Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
title_short Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
title_sort approbation of a new model of secondary damage after traumatic brain injury based on reprogrammed rat embryo fibroblasts
topic Biochemistry, Biophysics, and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575796/
https://www.ncbi.nlm.nih.gov/pubmed/37833611
http://dx.doi.org/10.1134/S1607672923700345
work_keys_str_mv AT rykunovaeb approbationofanewmodelofsecondarydamageaftertraumaticbraininjurybasedonreprogrammedratembryofibroblasts
AT mikeladzema approbationofanewmodelofsecondarydamageaftertraumaticbraininjurybasedonreprogrammedratembryofibroblasts
AT utepovaia approbationofanewmodelofsecondarydamageaftertraumaticbraininjurybasedonreprogrammedratembryofibroblasts
AT chupakhinon approbationofanewmodelofsecondarydamageaftertraumaticbraininjurybasedonreprogrammedratembryofibroblasts
AT guzhovaiv approbationofanewmodelofsecondarydamageaftertraumaticbraininjurybasedonreprogrammedratembryofibroblasts
AT lazarevvf approbationofanewmodelofsecondarydamageaftertraumaticbraininjurybasedonreprogrammedratembryofibroblasts

Ejemplares similares