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Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity
Obesity adversely affects bone and fat metabolism in mice and humans. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been shown to improve glucose metabolism and bone homeostasis in obesity. However, the impact of omega-3 PUFAs on bone marrow adipose tissue (BMAT) and bone marrow stromal c...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575870/ https://www.ncbi.nlm.nih.gov/pubmed/37833362 http://dx.doi.org/10.1038/s42003-023-05407-8 |
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| author | Benova, Andrea Ferencakova, Michaela Bardova, Kristina Funda, Jiri Prochazka, Jan Spoutil, Frantisek Cajka, Tomas Dzubanova, Martina Balcaen, Tim Kerckhofs, Greet Willekens, Wouter van Lenthe, G. Harry Charyyeva, Arzuv Alquicer, Glenda Pecinova, Alena Mracek, Tomas Horakova, Olga Coupeau, Roman Hansen, Morten Svarer Rossmeisl, Martin Kopecky, Jan Tencerova, Michaela |
| author_facet | Benova, Andrea Ferencakova, Michaela Bardova, Kristina Funda, Jiri Prochazka, Jan Spoutil, Frantisek Cajka, Tomas Dzubanova, Martina Balcaen, Tim Kerckhofs, Greet Willekens, Wouter van Lenthe, G. Harry Charyyeva, Arzuv Alquicer, Glenda Pecinova, Alena Mracek, Tomas Horakova, Olga Coupeau, Roman Hansen, Morten Svarer Rossmeisl, Martin Kopecky, Jan Tencerova, Michaela |
| author_sort | Benova, Andrea |
| collection | PubMed |
| description | Obesity adversely affects bone and fat metabolism in mice and humans. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been shown to improve glucose metabolism and bone homeostasis in obesity. However, the impact of omega-3 PUFAs on bone marrow adipose tissue (BMAT) and bone marrow stromal cell (BMSC) metabolism has not been intensively studied yet. In the present study we demonstrated that omega-3 PUFA supplementation in high fat diet (HFD + F) improved bone parameters, mechanical properties along with decreased BMAT in obese mice when compared to the HFD group. Primary BMSCs isolated from HFD + F mice showed decreased adipocyte and higher osteoblast differentiation with lower senescent phenotype along with decreased osteoclast formation suggesting improved bone marrow microenvironment promoting bone formation in mice. Thus, our study highlights the beneficial effects of omega-3 PUFA-enriched diet on bone and cellular metabolism and its potential use in the treatment of metabolic bone diseases. |
| format | Online Article Text |
| id | pubmed-10575870 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105758702023-10-15 Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity Benova, Andrea Ferencakova, Michaela Bardova, Kristina Funda, Jiri Prochazka, Jan Spoutil, Frantisek Cajka, Tomas Dzubanova, Martina Balcaen, Tim Kerckhofs, Greet Willekens, Wouter van Lenthe, G. Harry Charyyeva, Arzuv Alquicer, Glenda Pecinova, Alena Mracek, Tomas Horakova, Olga Coupeau, Roman Hansen, Morten Svarer Rossmeisl, Martin Kopecky, Jan Tencerova, Michaela Commun Biol Article Obesity adversely affects bone and fat metabolism in mice and humans. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been shown to improve glucose metabolism and bone homeostasis in obesity. However, the impact of omega-3 PUFAs on bone marrow adipose tissue (BMAT) and bone marrow stromal cell (BMSC) metabolism has not been intensively studied yet. In the present study we demonstrated that omega-3 PUFA supplementation in high fat diet (HFD + F) improved bone parameters, mechanical properties along with decreased BMAT in obese mice when compared to the HFD group. Primary BMSCs isolated from HFD + F mice showed decreased adipocyte and higher osteoblast differentiation with lower senescent phenotype along with decreased osteoclast formation suggesting improved bone marrow microenvironment promoting bone formation in mice. Thus, our study highlights the beneficial effects of omega-3 PUFA-enriched diet on bone and cellular metabolism and its potential use in the treatment of metabolic bone diseases. Nature Publishing Group UK 2023-10-14 /pmc/articles/PMC10575870/ /pubmed/37833362 http://dx.doi.org/10.1038/s42003-023-05407-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Benova, Andrea Ferencakova, Michaela Bardova, Kristina Funda, Jiri Prochazka, Jan Spoutil, Frantisek Cajka, Tomas Dzubanova, Martina Balcaen, Tim Kerckhofs, Greet Willekens, Wouter van Lenthe, G. Harry Charyyeva, Arzuv Alquicer, Glenda Pecinova, Alena Mracek, Tomas Horakova, Olga Coupeau, Roman Hansen, Morten Svarer Rossmeisl, Martin Kopecky, Jan Tencerova, Michaela Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity |
| title | Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity |
| title_full | Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity |
| title_fullStr | Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity |
| title_full_unstemmed | Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity |
| title_short | Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity |
| title_sort | omega-3 pufas prevent bone impairment and bone marrow adiposity in mouse model of obesity |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575870/ https://www.ncbi.nlm.nih.gov/pubmed/37833362 http://dx.doi.org/10.1038/s42003-023-05407-8 |
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