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Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device
Sarcopenia is a progressive loss of muscle mass and strength that is associated with increasing the risk of falls, musculoskeletal diseases, and chronic metabolic diseases. However, the animal models adopted to study sarcopenia face limitations since the functional tests conducted on human cannot be...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575903/ https://www.ncbi.nlm.nih.gov/pubmed/37833409 http://dx.doi.org/10.1038/s41598-023-44748-6 |
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author | Kim, Seung-Rok Lee, Ey-In Kim, Yongnyun Cho, Sang Wouk Hong, Namki Rhee, Yumie Park, Jin-Woo |
author_facet | Kim, Seung-Rok Lee, Ey-In Kim, Yongnyun Cho, Sang Wouk Hong, Namki Rhee, Yumie Park, Jin-Woo |
author_sort | Kim, Seung-Rok |
collection | PubMed |
description | Sarcopenia is a progressive loss of muscle mass and strength that is associated with increasing the risk of falls, musculoskeletal diseases, and chronic metabolic diseases. However, the animal models adopted to study sarcopenia face limitations since the functional tests conducted on human cannot be directly adapted to animals because the animals do not follow instructions. Moreover, current preclinical research tools for muscle function assessment, such as the rotarod, grip strength, and treadmill, have limitations, including low-intensity simple movements, evaluator subjectivity, and limited power indicators. Hence, in this study, we present a new jumping-power assessment tool in a preclinical rodent model to demonstrate muscle functions. To overcome the light weight and command issues in the rodent model, we developed an electrical stimulation-assisted jump power assessment device. Precisely, the device utilizes a load cell with a 0.1 g resolution and a 50 points/s data acquisition rate to capture the short period of the mouse jump. Additionally, interdigitated electrodes are used to electrically stimulate the mice and make them jump. While our primary focus in this article is the validation of the newly developed jump power assessment device, it is worth noting that this tool has several potential utilities. These include the phenotypic comparison of sarcopenia models, the exploration of muscle function reduction mechanisms, muscle function-related blood biomarkers, and the evaluation of drug intervention effects. |
format | Online Article Text |
id | pubmed-10575903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105759032023-10-15 Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device Kim, Seung-Rok Lee, Ey-In Kim, Yongnyun Cho, Sang Wouk Hong, Namki Rhee, Yumie Park, Jin-Woo Sci Rep Article Sarcopenia is a progressive loss of muscle mass and strength that is associated with increasing the risk of falls, musculoskeletal diseases, and chronic metabolic diseases. However, the animal models adopted to study sarcopenia face limitations since the functional tests conducted on human cannot be directly adapted to animals because the animals do not follow instructions. Moreover, current preclinical research tools for muscle function assessment, such as the rotarod, grip strength, and treadmill, have limitations, including low-intensity simple movements, evaluator subjectivity, and limited power indicators. Hence, in this study, we present a new jumping-power assessment tool in a preclinical rodent model to demonstrate muscle functions. To overcome the light weight and command issues in the rodent model, we developed an electrical stimulation-assisted jump power assessment device. Precisely, the device utilizes a load cell with a 0.1 g resolution and a 50 points/s data acquisition rate to capture the short period of the mouse jump. Additionally, interdigitated electrodes are used to electrically stimulate the mice and make them jump. While our primary focus in this article is the validation of the newly developed jump power assessment device, it is worth noting that this tool has several potential utilities. These include the phenotypic comparison of sarcopenia models, the exploration of muscle function reduction mechanisms, muscle function-related blood biomarkers, and the evaluation of drug intervention effects. Nature Publishing Group UK 2023-10-13 /pmc/articles/PMC10575903/ /pubmed/37833409 http://dx.doi.org/10.1038/s41598-023-44748-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kim, Seung-Rok Lee, Ey-In Kim, Yongnyun Cho, Sang Wouk Hong, Namki Rhee, Yumie Park, Jin-Woo Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
title | Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
title_full | Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
title_fullStr | Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
title_full_unstemmed | Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
title_short | Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
title_sort | preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575903/ https://www.ncbi.nlm.nih.gov/pubmed/37833409 http://dx.doi.org/10.1038/s41598-023-44748-6 |
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