MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)

The most prevalent genetic form of inherited arrhythmogenic cardiomyopathy (ACM) is caused by mutations in desmosomal plakophilin-2 (PKP2). By studying pathogenic deletion mutations in the desmosomal protein PKP2, here we identify a general mechanism by which PKP2 delocalization restricts actomyosin...

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Detalles Bibliográficos
Autores principales: García-Quintáns, Nieves, Sacristán, Silvia, Márquez-López, Cristina, Sánchez-Ramos, Cristina, Martinez-de-Benito, Fernando, Siniscalco, David, González-Guerra, Andrés, Camafeita, Emilio, Roche-Molina, Marta, Lytvyn, Mariya, Morera, David, Guillen, María I., Sanguino, María A., Sanz-Rosa, David, Martín-Pérez, Daniel, Garcia, Ricardo, Bernal, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575922/
https://www.ncbi.nlm.nih.gov/pubmed/37833253
http://dx.doi.org/10.1038/s41467-023-41981-5

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