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Anti-angiogenic therapy using the multi-tyrosine kinase inhibitor Regorafenib enhances tumor progression in a transgenic mouse model of ß-cell carcinogenesis

BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) represent a distinct hypervascularized tumor entity, often diagnosed at metastatic stage. Therapeutic efficacy of anti-angiogenic multi-kinase inhibitors is frequently limited by primary or acquired resistance in vivo. This study aimed to characte...

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Detalles Bibliográficos
Autores principales:	Egidi, Maren Juliane, Krug, Sebastian, Haybaeck, Johannes, Michl, Patrick, Griesmann, Heidi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575939/ https://www.ncbi.nlm.nih.gov/pubmed/37620408 http://dx.doi.org/10.1038/s41416-023-02389-6

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