Structural insights into the complex of oncogenic KRas4B(G12V) and Rgl2, a RalA/B activator

About a quarter of total human cancers carry mutations in Ras isoforms. Accumulating evidence suggests that small GTPases, RalA, and RalB, and their activators, Ral guanine nucleotide exchange factors (RalGEFs), play an essential role in oncogenic Ras-induced signalling. We studied the interaction b...

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Detalles Bibliográficos
Autores principales: Tariq, Mishal, Ikeya, Teppei, Togashi, Naoyuki, Fairall, Louise, Kamei, Shun, Mayooramurugan, Sannojah, Abbott, Lauren R, Hasan, Anab, Bueno-Alejo, Carlos, Sukegawa, Sakura, Romartinez-Alonso, Beatriz, Muro Campillo, Miguel Angel, Hudson, Andrew J, Ito, Yutaka, Schwabe, John WR, Dominguez, Cyril, Tanaka, Kayoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576006/
https://www.ncbi.nlm.nih.gov/pubmed/37833074
http://dx.doi.org/10.26508/lsa.202302080

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