Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility

RNA-binding proteins (RBPs) are crucial regulators of gene expression, often composed of defined domains interspersed with flexible, intrinsically disordered regions. Determining the structure of ribonucleoprotein (RNP) complexes involving such RBPs necessitates integrative structural modeling due t...

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Detalles Bibliográficos
Autores principales: Dorn, Georg, Gmeiner, Christoph, de Vries, Tebbe, Dedic, Emil, Novakovic, Mihajlo, Damberger, Fred F., Maris, Christophe, Finol, Esteban, Sarnowski, Chris P., Kohlbrecher, Joachim, Welsh, Timothy J., Bolisetty, Sreenath, Mezzenga, Raffaele, Aebersold, Ruedi, Leitner, Alexander, Yulikov, Maxim, Jeschke, Gunnar, Allain, Frédéric H.-T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576089/
https://www.ncbi.nlm.nih.gov/pubmed/37833274
http://dx.doi.org/10.1038/s41467-023-42012-z

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