Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription

Regulation of global transcription output is important for normal development and disease, but little is known about the mechanisms involved. DNA topoisomerase I (TOP1) is an enzyme well-known for its role in relieving DNA supercoils for enabling transcription. Here, we report a non-enzymatic functi...

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Detalles Bibliográficos
Autores principales: Lau, Mei Sheng, Hu, Zhenhua, Zhao, Xiaodan, Tan, Yaw Sing, Liu, Jinyue, Huang, Hua, Yeo, Clarisse Jingyi, Leong, Hwei Fen, Grinchuk, Oleg V., Chan, Justin Kaixuan, Yan, Jie, Tee, Wee-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576097/
https://www.ncbi.nlm.nih.gov/pubmed/37833256
http://dx.doi.org/10.1038/s41467-023-42078-9

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